Objective: WHO/UNICEF/ICCIDD recommend a median urinary iodine concentration (UIC) in pregnant women between 150 µg/L and 249 µg/L. In the present study, we evaluated whether in the urban area of Cassino (central Italy), following a national salt iodination program (30 mg/Kg) introduced in 2005, the increased demand of iodine during pregnancy was satisfied. Research Methods & Procedures: Between January 2016 and April 2017, 99 pregnant women were enrolled to evaluate UIC in morning spot urine samples, serum level of thyrotropin, free-thyroxine, anti-thyroglobulin, anti-thyroperoxidase autoantibodies, and thyroid volume by ultrasonography. Eighty clinically healthy non-pregnant women have been evaluated as control. Results: The median UIC was of 97.7 µg/L and 110.3 µg/L, respectively, in control and pregnant women. A significant increase (p<0.001) of median thyroid volume was observed in pregnant women, with respect to control women being, respectively, 10.4 ml (range 3.68-19.49 ml) and 7.16 ml (range 2.57-14.00 ml). A positive correlation was found between thyroid volume and anthropometric parameters, while an inverse correlation was observed between free-thyroxine serum levels and anthropometric parameters. Conclusions: This observational study demonstrated that the majority of pregnant women and their fetuses appear to be not protected by the detrimental consequences of iodine deficiency. Therefore, the identification of new strategies capable to increase the knowledge of and awareness in the general population of the beneficial effects of iodine supplementation during pregnancy is highly required.

Iodine deficiency in pregnancy. Still a health issue for the women of Cassino city, Italy / Tuccilli, Chiara; Baldini, Enke; Truppa, Elia; D'Auria, Bruno; De Quattro, Domenico; Cacciola, Giovanni; Aceti, Tommaso; Cirillo, Giovanni; Faiola, Antonio; Indigeno, Patrizia; D'Aliesio, Lorella; Gazzellone, Fiorella; Bononi, Marco; D'Armiento, Eleonora; Carbotta, Giovanni; Pironi, Daniele; Catania, Antonio; Sorrenti, Salvatore; Ulisse, Salvatore. - In: NUTRITION. - ISSN 0899-9007. - ELETTRONICO. - 50:(2018), pp. 60-65. [10.1016/j.nut.2017.11.007]

Iodine deficiency in pregnancy. Still a health issue for the women of Cassino city, Italy

Tuccilli, Chiara
Membro del Collaboration Group
;
Baldini, Enke
Membro del Collaboration Group
;
INDIGENO, Patrizia
Membro del Collaboration Group
;
D'ALIESIO, LORELLA
Membro del Collaboration Group
;
GAZZELLONE, FIORELLA
Membro del Collaboration Group
;
Bononi, Marco
Membro del Collaboration Group
;
D'Armiento, Eleonora
Membro del Collaboration Group
;
Carbotta, Giovanni
Membro del Collaboration Group
;
Pironi, Daniele
Membro del Collaboration Group
;
Catania, Antonio;Sorrenti, Salvatore
Membro del Collaboration Group
;
Ulisse, Salvatore
Membro del Collaboration Group
2018

Abstract

Objective: WHO/UNICEF/ICCIDD recommend a median urinary iodine concentration (UIC) in pregnant women between 150 µg/L and 249 µg/L. In the present study, we evaluated whether in the urban area of Cassino (central Italy), following a national salt iodination program (30 mg/Kg) introduced in 2005, the increased demand of iodine during pregnancy was satisfied. Research Methods & Procedures: Between January 2016 and April 2017, 99 pregnant women were enrolled to evaluate UIC in morning spot urine samples, serum level of thyrotropin, free-thyroxine, anti-thyroglobulin, anti-thyroperoxidase autoantibodies, and thyroid volume by ultrasonography. Eighty clinically healthy non-pregnant women have been evaluated as control. Results: The median UIC was of 97.7 µg/L and 110.3 µg/L, respectively, in control and pregnant women. A significant increase (p<0.001) of median thyroid volume was observed in pregnant women, with respect to control women being, respectively, 10.4 ml (range 3.68-19.49 ml) and 7.16 ml (range 2.57-14.00 ml). A positive correlation was found between thyroid volume and anthropometric parameters, while an inverse correlation was observed between free-thyroxine serum levels and anthropometric parameters. Conclusions: This observational study demonstrated that the majority of pregnant women and their fetuses appear to be not protected by the detrimental consequences of iodine deficiency. Therefore, the identification of new strategies capable to increase the knowledge of and awareness in the general population of the beneficial effects of iodine supplementation during pregnancy is highly required.
2018
Goiter; iodine deficiency disorders; iodine supplementation; pregnancy; thyroid hormones; endocrinology, diabetes and metabolism; nutrition and dietetics
01 Pubblicazione su rivista::01a Articolo in rivista
Iodine deficiency in pregnancy. Still a health issue for the women of Cassino city, Italy / Tuccilli, Chiara; Baldini, Enke; Truppa, Elia; D'Auria, Bruno; De Quattro, Domenico; Cacciola, Giovanni; Aceti, Tommaso; Cirillo, Giovanni; Faiola, Antonio; Indigeno, Patrizia; D'Aliesio, Lorella; Gazzellone, Fiorella; Bononi, Marco; D'Armiento, Eleonora; Carbotta, Giovanni; Pironi, Daniele; Catania, Antonio; Sorrenti, Salvatore; Ulisse, Salvatore. - In: NUTRITION. - ISSN 0899-9007. - ELETTRONICO. - 50:(2018), pp. 60-65. [10.1016/j.nut.2017.11.007]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1088562
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