["STRESSEN" in the treatment of psycho-physical stress and hyperhomocysteinemia in patients with migraine without aura].

A previous clinical trial evidenced, in patients affected by migraine without aura, that treatment with medicinal product STRESSEN determined a reduction of homocysteinemia and an improved general state of health, also if the protocol had not provided for the latter evaluation. The aim of this study is to confirm, in a similar population, the efficacy of STRESSEN on hyperhomocysteinemia and to control the psycho-physical state of the patients by means of specific parameters. 20 hyperhomocysteinemic (> 15 micromol/ 1) patients suffering from psycho-physical stress and migraine without aura were enrolled. The efficacy of a 30 days treatment with STRESSEN was evaluated through dosage of this amino acid and through a questionnaire on the general state of health. Homocysteinemia was reduced of 52.1% (P < 0.001) and the score representing the general state of health decreased from 1.63 +/- 0.38 to 0.78 +/- 0.12 (P < 0.001). This study supported the effectiveness of STRESSEN treatment to restore physiological profile of homocysteinemia and to improve the psycho-physical conditions, usually altered by stress for which the drug is already indicated.