Background Migraine is one of the most disabling neurological disorders. The current pharmacological armamentarium is not satisfying for a large proportion of patients because the responder rate does not exceed 50% on average and the most effective drugs often induce intolerable side effects. During recent years, noninvasive central and peripheral neuromodulation methods have been explored for migraine treatment. Overview A review of the available evidence suggests that noninvasive neuromodulation techniques could be beneficial for migraine patients. The transcranial stimulation methods allow modulating selectively cortical activity and can thus be curtailed to the patient's pathophysiological profile, while transcutaneous stimulation of pericranial nerves likely modulates central pain control centers. Occipital single-pulse transcranial magnetic stimulation and transcutaneous supraorbital stimulation have the strongest evidence respectively for acute and preventive treatment. Transcranial direct current stimulation and repetitive magnetic stimulation are promising in pilot studies, but large sham-controlled trials are not yet available. Conclusions The noninvasive neurostimulation methods are promising for migraine treatment and devoid of serious adverse effects allowing their combination with drug therapies. Their application in clinical practice will depend on the industry's capacity to develop portable and user-friendly devices, and on the scientists' capacity to prove their efficacy in randomized sham-controlled trials.

Noninvasive neurostimulation methods for migraine therapy. The available evidence / Schoenen, Jean; Baschi, Roberta; Magis, Delphine; Coppola, Gianluca. - In: CEPHALALGIA. - ISSN 0333-1024. - STAMPA. - 36:12(2016), pp. 1170-1180. [10.1177/0333102416636022]

Noninvasive neurostimulation methods for migraine therapy. The available evidence

Coppola, Gianluca
2016

Abstract

Background Migraine is one of the most disabling neurological disorders. The current pharmacological armamentarium is not satisfying for a large proportion of patients because the responder rate does not exceed 50% on average and the most effective drugs often induce intolerable side effects. During recent years, noninvasive central and peripheral neuromodulation methods have been explored for migraine treatment. Overview A review of the available evidence suggests that noninvasive neuromodulation techniques could be beneficial for migraine patients. The transcranial stimulation methods allow modulating selectively cortical activity and can thus be curtailed to the patient's pathophysiological profile, while transcutaneous stimulation of pericranial nerves likely modulates central pain control centers. Occipital single-pulse transcranial magnetic stimulation and transcutaneous supraorbital stimulation have the strongest evidence respectively for acute and preventive treatment. Transcranial direct current stimulation and repetitive magnetic stimulation are promising in pilot studies, but large sham-controlled trials are not yet available. Conclusions The noninvasive neurostimulation methods are promising for migraine treatment and devoid of serious adverse effects allowing their combination with drug therapies. Their application in clinical practice will depend on the industry's capacity to develop portable and user-friendly devices, and on the scientists' capacity to prove their efficacy in randomized sham-controlled trials.
2016
transcranial direct current stimulation; transcranial magnetic stimulation; transcutaneous suprave stimulation; evidence-based medicine; humans; migraine disorders; transcranial direct current stimulation; transcranial magnetic stimulation; transcutaneous electric nerve stimulation; treatment outcome; neurology (clinical)orbital stimulation; vagus nerves
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Noninvasive neurostimulation methods for migraine therapy. The available evidence / Schoenen, Jean; Baschi, Roberta; Magis, Delphine; Coppola, Gianluca. - In: CEPHALALGIA. - ISSN 0333-1024. - STAMPA. - 36:12(2016), pp. 1170-1180. [10.1177/0333102416636022]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1088162
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