Sir—In their report, Mona Boaz and colleagues1 conclude that, in haemodialysis patients who have increased oxidative stress and are at high risk of atherosclerotic complications, 800 IU vitamin E daily reduces the risk of vascular accidents, including myocardial infarction. The results are consistent with our study, in which we show that vitamin E interferes with one of the most important mechanisms in the initiation and progression of atherosclerosis— cholesterol accumulation in the vessel wall.2 We have shown that autologous radiolabelled LDL injected in patients, who underwent carotid endarterectomy, localised in the macrophages of atherosclerotic plaque and that 900 mg vitamin E daily almost completely prevented this effect.2
Vitamin E supplementation / Violi, F; Micheletta, F; Iuliano, Luigi. - In: THE LANCET. - ISSN 0140-6736. - 357(9256):(2001), pp. 632-633. [10.1016/S0140-6736(05)71418-5]
Vitamin E supplementation.
IULIANO, Luigi
2001
Abstract
Sir—In their report, Mona Boaz and colleagues1 conclude that, in haemodialysis patients who have increased oxidative stress and are at high risk of atherosclerotic complications, 800 IU vitamin E daily reduces the risk of vascular accidents, including myocardial infarction. The results are consistent with our study, in which we show that vitamin E interferes with one of the most important mechanisms in the initiation and progression of atherosclerosis— cholesterol accumulation in the vessel wall.2 We have shown that autologous radiolabelled LDL injected in patients, who underwent carotid endarterectomy, localised in the macrophages of atherosclerotic plaque and that 900 mg vitamin E daily almost completely prevented this effect.2I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
