Objective Obesity is one of the major health challenges throughout the world. The association between obesity and diabetes is well established because 90% of patients with type 2 diabetes mellitus (T2DM) show excess body weight. The aim of the study was to evaluate the effect of laparoscopic sleeve gastrectomy (LSG) on morbid obesity and type 2 diabetes (T2DM) in the longterm follow-up. Methods One hundred ninety-five obese patients, 78 with T2DM, were evaluated before and after LSG up to 10 years, to identify complete diabetes remission (FPG < 100 mg/dl, A1c < 6.0%), partial remission (FPG 100–125 mg/dl, A1c < 6.5%), or relapse. Results Before surgery, body weight and BMI were 123 ± 21 kg and 44.6 ± 6.8 kg/m2 respectively; at a mean follow-up of 7 years (range 4–10), body weight was 104.9 ± 18 kg and BMI 37 ± 6 kg/m2 . Minimum weight was reached after 2 years. T2DM remission was observed in 66, 57, and 52% at short (< 2 years), medium (2–5 years), and long-term (> 5 years) follow-up respectively. Furthermore, 45.2% maintained complete remission for at least 5 years and about 36% showed a persistent but improved diabetes. None of the patients cured from diabetes had a duration disease greater than 8 years and a glycemic control requiring insulin. The prevalence of hypertension and dyslipidemia significantly decreased from 49 to 35% and from 51 to 40% respectively. Conclusions LSG significantly improves body weight, diabetes, hypertension, and dyslipidemia in long-term follow-up

Long-term metabolic effects of laparoscopic sleeve gastrectomy / Capoccia, Danila; Coccia, Federica; Guarisco, Gloria; Testa, Moira; Rendina, Roberta; Abbatini, Francesca; Silecchia, Gianfranco; Leonetti, Frida. - In: OBESITY SURGERY. - ISSN 0960-8923. - STAMPA. - 28:8(2018), pp. 2289-2296. [10.1007/s11695-018-3153-8]

Long-term metabolic effects of laparoscopic sleeve gastrectomy

Capoccia, Danila
Data Curation
;
Coccia, Federica
Writing – Original Draft Preparation
;
GUARISCO, Gloria
Methodology
;
TESTA, MOIRA
Software
;
Rendina, Roberta
Software
;
Abbatini, Francesca
Data Curation
;
Silecchia, Gianfranco
Supervision
;
Leonetti, Frida
Supervision
2018

Abstract

Objective Obesity is one of the major health challenges throughout the world. The association between obesity and diabetes is well established because 90% of patients with type 2 diabetes mellitus (T2DM) show excess body weight. The aim of the study was to evaluate the effect of laparoscopic sleeve gastrectomy (LSG) on morbid obesity and type 2 diabetes (T2DM) in the longterm follow-up. Methods One hundred ninety-five obese patients, 78 with T2DM, were evaluated before and after LSG up to 10 years, to identify complete diabetes remission (FPG < 100 mg/dl, A1c < 6.0%), partial remission (FPG 100–125 mg/dl, A1c < 6.5%), or relapse. Results Before surgery, body weight and BMI were 123 ± 21 kg and 44.6 ± 6.8 kg/m2 respectively; at a mean follow-up of 7 years (range 4–10), body weight was 104.9 ± 18 kg and BMI 37 ± 6 kg/m2 . Minimum weight was reached after 2 years. T2DM remission was observed in 66, 57, and 52% at short (< 2 years), medium (2–5 years), and long-term (> 5 years) follow-up respectively. Furthermore, 45.2% maintained complete remission for at least 5 years and about 36% showed a persistent but improved diabetes. None of the patients cured from diabetes had a duration disease greater than 8 years and a glycemic control requiring insulin. The prevalence of hypertension and dyslipidemia significantly decreased from 49 to 35% and from 51 to 40% respectively. Conclusions LSG significantly improves body weight, diabetes, hypertension, and dyslipidemia in long-term follow-up
2018
bariatric surgery; obesity; type 2 diabetes
01 Pubblicazione su rivista::01a Articolo in rivista
Long-term metabolic effects of laparoscopic sleeve gastrectomy / Capoccia, Danila; Coccia, Federica; Guarisco, Gloria; Testa, Moira; Rendina, Roberta; Abbatini, Francesca; Silecchia, Gianfranco; Leonetti, Frida. - In: OBESITY SURGERY. - ISSN 0960-8923. - STAMPA. - 28:8(2018), pp. 2289-2296. [10.1007/s11695-018-3153-8]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1087315
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