In animal models it is often possible to block Th1-mediated autoimmunity by deviating the response to Th2. In this article, Graham Rook and colleagues argue that this might prove a dangerous strategy in humans, and that we should distinguish between potentially pathogenic Th2 effector cells, and Th2-like physiological regulators of Th1 responses. The regulators might be triggered by appropriate Th1-inducing bacterial vaccines.
Bacterial vaccines for the treatment of multiple sclerosis and other autoimmune diseases / Rook, G.; Ristori, Giovanni; Salvetti, Marco; Giovannoni, G.; Thompson, E. J.; Stanfort, Jl. - In: IMMUNOLOGY TODAY. - ISSN 0167-5699. - 21(10):(2000), pp. 503-508. [10.1016/S0167-5699(00)01700-X]
Bacterial vaccines for the treatment of multiple sclerosis and other autoimmune diseases.
RISTORI, GIOVANNI;SALVETTI, Marco;
2000
Abstract
In animal models it is often possible to block Th1-mediated autoimmunity by deviating the response to Th2. In this article, Graham Rook and colleagues argue that this might prove a dangerous strategy in humans, and that we should distinguish between potentially pathogenic Th2 effector cells, and Th2-like physiological regulators of Th1 responses. The regulators might be triggered by appropriate Th1-inducing bacterial vaccines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
