Intravenous immunoglobulin administered at replacement dosages modulates innate and adaptive immune cells in primary antibody deficiencies (PAD) in a different manner to what observed when high dosages are used or when their effect is analyzed byin vitroexperimental conditions. The effects seem to be beneficial on innate cells in that dendritic cells maturate, pro-inflammatory monocytes decrease, and neutrophil function is preserved. The effects are less clear on adaptive immune cells. IVIg induced a transient increase of Treg and a long-term increase of CD4 cells. More complex and less understood is the interplay of IVIg with defective B cells of PAD patients. The paucity of data underlies the need of more studies on patients with PAD before drawing conclusions on thein vivomechanisms of action of IVIg based onin vitroinvestigations.

Modulatory Effects of Antibody Replacement Therapy to Innate and Adaptive Immune Cells / Quinti, Isabella; Mitrevski, Milica. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 8:(2017), p. 697. [10.3389/fimmu.2017.00697]

Modulatory Effects of Antibody Replacement Therapy to Innate and Adaptive Immune Cells

Quinti, Isabella;Mitrevski, Milica
2017

Abstract

Intravenous immunoglobulin administered at replacement dosages modulates innate and adaptive immune cells in primary antibody deficiencies (PAD) in a different manner to what observed when high dosages are used or when their effect is analyzed byin vitroexperimental conditions. The effects seem to be beneficial on innate cells in that dendritic cells maturate, pro-inflammatory monocytes decrease, and neutrophil function is preserved. The effects are less clear on adaptive immune cells. IVIg induced a transient increase of Treg and a long-term increase of CD4 cells. More complex and less understood is the interplay of IVIg with defective B cells of PAD patients. The paucity of data underlies the need of more studies on patients with PAD before drawing conclusions on thein vivomechanisms of action of IVIg based onin vitroinvestigations.
2017
IVIg replacement; X-linked agammaglobulinemia; adaptive immunity; common variable immune disorders; in vivo; innate immunity
01 Pubblicazione su rivista::01a Articolo in rivista
Modulatory Effects of Antibody Replacement Therapy to Innate and Adaptive Immune Cells / Quinti, Isabella; Mitrevski, Milica. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 8:(2017), p. 697. [10.3389/fimmu.2017.00697]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1086398
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