Ischemic heart disease is the leading cause of serious morbidity and mortality in Western society. One of the therapeutic approaches is based on the use of thrombolitic drugs that promote clot lysis. Even if the mechanisms leading to clot lysis are not completely understood, it is widely accepted that they depend on the complex biochemical reactions that occur among fibrin fibers and fibrinolitic agents, and by their ready diffusion into the fibers. Here we investigate the effects of specific anions on the architecture of protofibrils within fibrin fibers in fibrin gels prepared in a para-physiological solution. The results obtained through small-angle X-ray scattering (SAXS) demonstrate that the characteristic axial and longitudinal repeat distances among protofibrils are strongly affected by the action of Cl(-) and F(-) anions.

Cl(-) and F(-) anions regulate the architecture of protofibrils in fibrin gel / Missori, M; Papi, M; Maulucci, G; Arcovito, G; Boumis, Giovanna; Bellelli, Andrea; Amiconi, Gino; DE SPIRITO, M.. - In: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. - ISSN 0175-7571. - STAMPA. - 39:(2010), pp. 1001-1006. [10.1007/s00249-009-0492-3]

Cl(-) and F(-) anions regulate the architecture of protofibrils in fibrin gel.

BOUMIS, Giovanna;BELLELLI, Andrea;AMICONI, Gino;
2010

Abstract

Ischemic heart disease is the leading cause of serious morbidity and mortality in Western society. One of the therapeutic approaches is based on the use of thrombolitic drugs that promote clot lysis. Even if the mechanisms leading to clot lysis are not completely understood, it is widely accepted that they depend on the complex biochemical reactions that occur among fibrin fibers and fibrinolitic agents, and by their ready diffusion into the fibers. Here we investigate the effects of specific anions on the architecture of protofibrils within fibrin fibers in fibrin gels prepared in a para-physiological solution. The results obtained through small-angle X-ray scattering (SAXS) demonstrate that the characteristic axial and longitudinal repeat distances among protofibrils are strongly affected by the action of Cl(-) and F(-) anions.
blood clotting; fibrin gel; light scattering
01 Pubblicazione su rivista::01a Articolo in rivista
Cl(-) and F(-) anions regulate the architecture of protofibrils in fibrin gel / Missori, M; Papi, M; Maulucci, G; Arcovito, G; Boumis, Giovanna; Bellelli, Andrea; Amiconi, Gino; DE SPIRITO, M.. - In: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. - ISSN 0175-7571. - STAMPA. - 39:(2010), pp. 1001-1006. [10.1007/s00249-009-0492-3]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/108415
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact