Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac homeostasis and function. Autophagy preserves cardiac structure and function under baseline conditions and is activated during stress, limiting damage under most conditions. It reduces injury and preserves cardiac function during ischemia. It also reduces chronic ischemic remodeling and mediates the cardiac adaptation to pressure overload by restricting misfolded protein accumulation, mitochondrial dysfunction, and oxidative stress. Impairment of autophagy is involved in the development of diabetes and aging-induced cardiac abnormalities. Autophagy defects contribute to the development of cardiac proteinopathy and doxorubicin-induced cardiomyopathy. However, massive activation of autophagy may be detrimental for the heart in certain stress conditions, such as reperfusion injury. In this review, we discuss recent evidence supporting the important role of autophagy and mitophagy in the regulation of cardiac homeostasis and adaptation to stress.

The role of autophagy in the heart / Sciarretta, Sebastiano; Maejima, Yasuhiro; Zablocki, Daniela; Sadoshima, Junichi. - In: ANNUAL REVIEW OF PHYSIOLOGY. - ISSN 0066-4278. - 80:(2018), pp. 1-26. [10.1146/annurev-physiol-021317-121427]

The role of autophagy in the heart

Sciarretta, Sebastiano;
2018

Abstract

Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac homeostasis and function. Autophagy preserves cardiac structure and function under baseline conditions and is activated during stress, limiting damage under most conditions. It reduces injury and preserves cardiac function during ischemia. It also reduces chronic ischemic remodeling and mediates the cardiac adaptation to pressure overload by restricting misfolded protein accumulation, mitochondrial dysfunction, and oxidative stress. Impairment of autophagy is involved in the development of diabetes and aging-induced cardiac abnormalities. Autophagy defects contribute to the development of cardiac proteinopathy and doxorubicin-induced cardiomyopathy. However, massive activation of autophagy may be detrimental for the heart in certain stress conditions, such as reperfusion injury. In this review, we discuss recent evidence supporting the important role of autophagy and mitophagy in the regulation of cardiac homeostasis and adaptation to stress.
2018
Autophagy; autosis; lysosome; mitophagy; protein quality control; proteinopathy; physiology
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The role of autophagy in the heart / Sciarretta, Sebastiano; Maejima, Yasuhiro; Zablocki, Daniela; Sadoshima, Junichi. - In: ANNUAL REVIEW OF PHYSIOLOGY. - ISSN 0066-4278. - 80:(2018), pp. 1-26. [10.1146/annurev-physiol-021317-121427]
File allegati a questo prodotto
File Dimensione Formato  
Sciarretta_Role-of-autophagy.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.29 MB
Formato Adobe PDF
1.29 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1084011
Citazioni
  • ???jsp.display-item.citation.pmc??? 112
  • Scopus 361
  • ???jsp.display-item.citation.isi??? 339
social impact