LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology. How these receptors affect cancer progression in humans remains largely unknown. Herein, we mined provisional data-bases in The Cancer Genome Atlas (TCGA) to compare expression of thirteen LRPs in ten common solid malignancies in patients. Our first goal was to determine the abundance of LRP mRNAs in each type of cancer. Our second goal was to determine whether expression of LRPs is associated with improved or worsened patient survival. In total, data from 4,629 patients were mined. In nine of ten cancers studied, the most abundantly expressed LRP was LRP1; however, a correlation between LRP1 mRNA expression and patient survival was observed only in bladder urothelial carcinoma. In this malignancy, high levels of LRP1 mRNA were associated with worsened patient survival. High levels of LDL receptor (LDLR) mRNA were associated with decreased patient survival in pancreatic adenocarcinoma. High levels of LRP10 mRNA were associated with decreased patient survival in hepatocellular carcinoma, lung adenocarcinoma, and pancreatic adenocarcinoma. LRP2 was the only LRP for which high levels of mRNA expression correlated with improved patient survival. This correlation was observed in renal clear cell carcinoma. Insights into LRP gene expression in human cancers and their effects on patient survival should guide future research.

Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival / Gonias, Steven L.; Karimi-Mostowfi, Nicki; Murray, Sarah S.; Mantuano, Elisabetta; Gilder, Andrew S.. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 12:10(2017). [10.1371/journal.pone.0186649]

Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival

Mantuano, Elisabetta;
2017

Abstract

LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology. How these receptors affect cancer progression in humans remains largely unknown. Herein, we mined provisional data-bases in The Cancer Genome Atlas (TCGA) to compare expression of thirteen LRPs in ten common solid malignancies in patients. Our first goal was to determine the abundance of LRP mRNAs in each type of cancer. Our second goal was to determine whether expression of LRPs is associated with improved or worsened patient survival. In total, data from 4,629 patients were mined. In nine of ten cancers studied, the most abundantly expressed LRP was LRP1; however, a correlation between LRP1 mRNA expression and patient survival was observed only in bladder urothelial carcinoma. In this malignancy, high levels of LRP1 mRNA were associated with worsened patient survival. High levels of LDL receptor (LDLR) mRNA were associated with decreased patient survival in pancreatic adenocarcinoma. High levels of LRP10 mRNA were associated with decreased patient survival in hepatocellular carcinoma, lung adenocarcinoma, and pancreatic adenocarcinoma. LRP2 was the only LRP for which high levels of mRNA expression correlated with improved patient survival. This correlation was observed in renal clear cell carcinoma. Insights into LRP gene expression in human cancers and their effects on patient survival should guide future research.
Biomarkers, Tumor; Humans; LDL-Receptor Related Proteins; Neoplasms; RNA, Messenger; Survival Analysis; Biochemistry, Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)
01 Pubblicazione su rivista::01a Articolo in rivista
Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival / Gonias, Steven L.; Karimi-Mostowfi, Nicki; Murray, Sarah S.; Mantuano, Elisabetta; Gilder, Andrew S.. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 12:10(2017). [10.1371/journal.pone.0186649]
File allegati a questo prodotto
File Dimensione Formato  
Gonias_Expression-LDL_2017.pdf

accesso aperto

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 3.15 MB
Formato Adobe PDF
3.15 MB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1083887
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 26
social impact