Autism spectrum disorders (ASDs) present a wide range of symptoms characterized by altered sociability, compromised communication and stereotypic/repetitive behaviors. These symptoms are caused by developmental changes, but the mechanisms remain largely unknown. Some lines of evidence suggest an impairment of the cholesterol/isoprenoid metabolism in the brain as a possible cause, but systematic analyses in rodent models of ASDs are lacking. Prenatal exposure to the antiepileptic drug valproate (VPA) is a risk factor for ASDs in humans and generates a well-established model for the disease in rodents. Here, we studied cholesterol/isoprenoid metabolism in different brain areas of infant, adolescent and adult rats prenatally exposed to VPA. VPA-treated rats present autistic-like symptoms, they show changes in cholesterol/isoprenoid homeostasis in some brain areas, a decreased number of oligodendrocytes and impaired myelination in the hippocampus. Together, our data suggest a relation between brain cholesterol/isoprenoid homeostasis and ASDs.

Altered brain cholesterol/isoprenoid metabolism in a rat model of autism spectrum disorders / Cartocci, Veronica; Catallo, Martina; Tempestilli, Massimo; Segatto, Marco; Pfrieger, Frank W.; Bronzuoli, Maria Rosanna; Scuderi, Caterina; Servadio, Michela; Trezza, Viviana; Pallottini, Valentina. - In: NEUROSCIENCE. - ISSN 0306-4522. - ELETTRONICO. - 372:21(2018), pp. 27-37. [10.1016/j.neuroscience.2017.12.053]

Altered brain cholesterol/isoprenoid metabolism in a rat model of autism spectrum disorders

Tempestilli, Massimo;Segatto, Marco;Bronzuoli, Maria Rosanna;Scuderi, Caterina;Servadio, Michela;Trezza, Viviana;
2018

Abstract

Autism spectrum disorders (ASDs) present a wide range of symptoms characterized by altered sociability, compromised communication and stereotypic/repetitive behaviors. These symptoms are caused by developmental changes, but the mechanisms remain largely unknown. Some lines of evidence suggest an impairment of the cholesterol/isoprenoid metabolism in the brain as a possible cause, but systematic analyses in rodent models of ASDs are lacking. Prenatal exposure to the antiepileptic drug valproate (VPA) is a risk factor for ASDs in humans and generates a well-established model for the disease in rodents. Here, we studied cholesterol/isoprenoid metabolism in different brain areas of infant, adolescent and adult rats prenatally exposed to VPA. VPA-treated rats present autistic-like symptoms, they show changes in cholesterol/isoprenoid homeostasis in some brain areas, a decreased number of oligodendrocytes and impaired myelination in the hippocampus. Together, our data suggest a relation between brain cholesterol/isoprenoid homeostasis and ASDs.
2018
3-hydroxy 3-methylglutaryl Coenzyme A reductase; autism; cholesterol; isoprenoid; rats; valproic acid; neuroscience (all)
01 Pubblicazione su rivista::01a Articolo in rivista
Altered brain cholesterol/isoprenoid metabolism in a rat model of autism spectrum disorders / Cartocci, Veronica; Catallo, Martina; Tempestilli, Massimo; Segatto, Marco; Pfrieger, Frank W.; Bronzuoli, Maria Rosanna; Scuderi, Caterina; Servadio, Michela; Trezza, Viviana; Pallottini, Valentina. - In: NEUROSCIENCE. - ISSN 0306-4522. - ELETTRONICO. - 372:21(2018), pp. 27-37. [10.1016/j.neuroscience.2017.12.053]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1083486
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