Objective: The aim of our study was to evaluate human papillomavirus (HPV) infection as a risk factor for cutaneous squamous cell carcinoma (SCC) in immunocompetent individuals. Design: Hospital-based case-control study. Setting: Referral center for dermatologic diseases for central and southern Italy. Participants: Consecutive patients with histologically confirmed cutaneous SCC (n = 46) and control subjects (n = 84) chosen by frequency matching (age and sex) among patients admitted with unrelated diseases. Main Outcome Measure: Infection with epidermodysplasia verruciformis-related HPV types, blindly assessed by serologic testing (viruslike particle enzyme-linked immunosorbent assay). Information was obtained on known potentially confounding risk factors (family history, history and signs of sun exposure, and pigmentary traits) and on history of HPV-related lesions and diseases, assessed by inter-view and examination by a dermatologist. Results: Positive serologic findings for HPV type 8 were associated with SCC (odds ratio, 3.2; 95% confidence interval, 1.3-7.9) independently of other risk factors, whereas positive serologic findings for HPV type 15 were negatively associated with SCC (odds ratio, 0.4; 95% confidence interval, 0.2-0.9). Other variables significantly associated with the tumor were family history of skin cancer, professional or recreational sun exposure, light eye color, high number of solar keratoses and seborrheic keratoses on the body surface, and residency in radon-emitting buildings. Conclusions: Positive serologic findings for HPV type 8 are associated with SCC occurrence in immunocompetent individuals. Viral infection could act as a cofactor in the tumor development, along with genetic predisposition, solar radiation, and other environmental exposures. if confirmed, these findings could open new perspectives for treatment and prevention of SCC.

Evidence for the association of human papillomavirus infection and cutaneous squamous cell carcinoma in immunocompetent individuals / Cinzia, Masini; Pawel G., Fuchs; Fabrizio, Gabrielli; Sabine, Stark; Francesco, Sera; Miriam, Ploner; Carmelo Franco, Melchi; Grazia, Primavera; Giulio, Pirchio; Orietta, Picconi; Pierpaolo, Petasecca; Cattaruzza, Maria Sofia; Herbert J., Pfister; Damiano, Abeni. - In: ARCHIVES OF DERMATOLOGY. - ISSN 0003-987X. - 139:7(2003), pp. 890-894. (Intervento presentato al convegno 20th World Congress of Dermatology tenutosi a PARIS, FRANCE nel JUL 03-05, 2002) [10.1001/archderm.139.7.890].

Evidence for the association of human papillomavirus infection and cutaneous squamous cell carcinoma in immunocompetent individuals

CATTARUZZA, Maria Sofia;
2003

Abstract

Objective: The aim of our study was to evaluate human papillomavirus (HPV) infection as a risk factor for cutaneous squamous cell carcinoma (SCC) in immunocompetent individuals. Design: Hospital-based case-control study. Setting: Referral center for dermatologic diseases for central and southern Italy. Participants: Consecutive patients with histologically confirmed cutaneous SCC (n = 46) and control subjects (n = 84) chosen by frequency matching (age and sex) among patients admitted with unrelated diseases. Main Outcome Measure: Infection with epidermodysplasia verruciformis-related HPV types, blindly assessed by serologic testing (viruslike particle enzyme-linked immunosorbent assay). Information was obtained on known potentially confounding risk factors (family history, history and signs of sun exposure, and pigmentary traits) and on history of HPV-related lesions and diseases, assessed by inter-view and examination by a dermatologist. Results: Positive serologic findings for HPV type 8 were associated with SCC (odds ratio, 3.2; 95% confidence interval, 1.3-7.9) independently of other risk factors, whereas positive serologic findings for HPV type 15 were negatively associated with SCC (odds ratio, 0.4; 95% confidence interval, 0.2-0.9). Other variables significantly associated with the tumor were family history of skin cancer, professional or recreational sun exposure, light eye color, high number of solar keratoses and seborrheic keratoses on the body surface, and residency in radon-emitting buildings. Conclusions: Positive serologic findings for HPV type 8 are associated with SCC occurrence in immunocompetent individuals. Viral infection could act as a cofactor in the tumor development, along with genetic predisposition, solar radiation, and other environmental exposures. if confirmed, these findings could open new perspectives for treatment and prevention of SCC.
2003
01 Pubblicazione su rivista::01a Articolo in rivista
Evidence for the association of human papillomavirus infection and cutaneous squamous cell carcinoma in immunocompetent individuals / Cinzia, Masini; Pawel G., Fuchs; Fabrizio, Gabrielli; Sabine, Stark; Francesco, Sera; Miriam, Ploner; Carmelo Franco, Melchi; Grazia, Primavera; Giulio, Pirchio; Orietta, Picconi; Pierpaolo, Petasecca; Cattaruzza, Maria Sofia; Herbert J., Pfister; Damiano, Abeni. - In: ARCHIVES OF DERMATOLOGY. - ISSN 0003-987X. - 139:7(2003), pp. 890-894. (Intervento presentato al convegno 20th World Congress of Dermatology tenutosi a PARIS, FRANCE nel JUL 03-05, 2002) [10.1001/archderm.139.7.890].
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/108308
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 110
  • ???jsp.display-item.citation.isi??? 90
social impact