The etiopathogenesis of otosclerosis is yet scarcely known. In this paper we focus on the immunoendocrine and infective aspects of the disorder. According to recent investigations the role played by cytokines and calcitonin's receptors appears to be crucial in the pathogenesis of otosclerosis. In addition, the ultrastructural and immunohistochemical evidence of virus specific antigens around the active otosclerotic focus suggest that virus can trigger and maintain an inflammatory disease.
[Otosclerosis. Immunoendocrine and infective aspects] / DI NARDO, Anna Maria; Parlapiano, C; Di Prima, M; Minni, A. - In: RIVISTA EUROPEA PER LE SCIENZE MEDICHE E FARMACOLOGICHE. - ISSN 0392-291X. - STAMPA. - 15:5-6(1993), pp. 213-218.