Background: Pathological and MRI-based evidence suggests that multiple brain structures are likely to be involved in functional disconnection between brain areas. Few studies have investigated resting-state functional connectivity (rsFC) in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). In this study, we investigated within- and between-network rsFC abnormalities in these two conditions. Methods: Twenty patients with PSP, 11 patients with CBS, and 16 healthy subjects (HS) underwent a resting-state fMRI study. Resting-state networks (RSNs) were extracted to evaluate within- and between-network rsFC using the Melodic and FSLNets software packages. results: Increased within-network rsFC was observed in both PSP and CBS patients, with a larger number of RSNs being involved in CBS. Within-network cerebellar rsFC positively correlated with mini-mental state examination scores in patients with PSP. Compared to healthy volunteers, PSP and CBS patients exhibit reduced functional connectivity between the lateral visual and auditory RSNs, with PSP patients additionally showing lower functional connectivity between the cerebellar and insular RSNs. Moreover, rsFC between the salience and executive-control RSNs was increased in patients with CBS compared to HS. conclusion: This study provides evidence of functional brain reorganization in both PSP and CBS. Increased within-network rsFC could represent a higher degree of synchronization in damaged brain areas, while between-network rsFC abnormalities may mainly reflect degeneration of long-range white matter fibers.

Abnormal resting-state functional connectivity in progressive supranuclear palsy and corticobasal syndrome / Bharti, Komal; Bologna, Matteo; Upadhyay, Neeraj; Piattella, Maria Cristina; Suppa, Antonio; Petsas, Nikolaos; Gianni', Costanza; Tona, Francesca; Berardelli, Alfredo; Pantano, Patrizia. - In: FRONTIERS IN NEUROLOGY. - ISSN 1664-2295. - 8:JUN(2017). [10.3389/fneur.2017.00248]

Abnormal resting-state functional connectivity in progressive supranuclear palsy and corticobasal syndrome

Bharti, Komal
Formal Analysis
;
Bologna, Matteo
Writing – Original Draft Preparation
;
Upadhyay, Neeraj
Membro del Collaboration Group
;
Piattella, Maria Cristina
Membro del Collaboration Group
;
Suppa, Antonio
Membro del Collaboration Group
;
Petsas, Nikolaos
Membro del Collaboration Group
;
Gianni', Costanza;Tona, Francesca
Membro del Collaboration Group
;
Berardelli, Alfredo
Supervision
;
Pantano, Patrizia
Supervision
2017

Abstract

Background: Pathological and MRI-based evidence suggests that multiple brain structures are likely to be involved in functional disconnection between brain areas. Few studies have investigated resting-state functional connectivity (rsFC) in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). In this study, we investigated within- and between-network rsFC abnormalities in these two conditions. Methods: Twenty patients with PSP, 11 patients with CBS, and 16 healthy subjects (HS) underwent a resting-state fMRI study. Resting-state networks (RSNs) were extracted to evaluate within- and between-network rsFC using the Melodic and FSLNets software packages. results: Increased within-network rsFC was observed in both PSP and CBS patients, with a larger number of RSNs being involved in CBS. Within-network cerebellar rsFC positively correlated with mini-mental state examination scores in patients with PSP. Compared to healthy volunteers, PSP and CBS patients exhibit reduced functional connectivity between the lateral visual and auditory RSNs, with PSP patients additionally showing lower functional connectivity between the cerebellar and insular RSNs. Moreover, rsFC between the salience and executive-control RSNs was increased in patients with CBS compared to HS. conclusion: This study provides evidence of functional brain reorganization in both PSP and CBS. Increased within-network rsFC could represent a higher degree of synchronization in damaged brain areas, while between-network rsFC abnormalities may mainly reflect degeneration of long-range white matter fibers.
Corticobasal syndrome; Functional connectivity; Progressive supranuclear palsy; Resting-state functional magnetic resonance imaging; Resting-state networks; Neurology; Neurology (clinical)
01 Pubblicazione su rivista::01a Articolo in rivista
Abnormal resting-state functional connectivity in progressive supranuclear palsy and corticobasal syndrome / Bharti, Komal; Bologna, Matteo; Upadhyay, Neeraj; Piattella, Maria Cristina; Suppa, Antonio; Petsas, Nikolaos; Gianni', Costanza; Tona, Francesca; Berardelli, Alfredo; Pantano, Patrizia. - In: FRONTIERS IN NEUROLOGY. - ISSN 1664-2295. - 8:JUN(2017). [10.3389/fneur.2017.00248]
File allegati a questo prodotto
File Dimensione Formato  
Bharti_abnormal-resting-state_2017.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.27 MB
Formato Adobe PDF
1.27 MB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1080974
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 19
social impact