Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.
Therapeutic implications of immunogenic cell death in human cancer / Palombo, Fabio; Focaccetti, Chiara; Barnaba, Vincenzo. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - STAMPA. - 4:JAN(2014), p. 503. [10.3389/fimmu.2013.00503]
Therapeutic implications of immunogenic cell death in human cancer
Focaccetti, ChiaraWriting – Original Draft Preparation
;Barnaba, Vincenzo
Supervision
2014
Abstract
Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.