Inhibition by ruboxyl, a nitroxyl derivative of daunorubicin, source preparation and 5-fluorouracil was compared in metastases of experimental colorectal carcinoma to murine liver. The indices of metastasis inhibition were 84.43 and 70%, respectively. In rats receiving the drugs by continuous intravenous infusion for 7 days, the number of metastases was reduced (ruboxyl--1.0 +/- 1.4; 5-fluorouracil 3.2 +/- 1.3.
Effect of Ruboxil (nitroxyl derivative of daunomicin) on hepatic metastases of colorectal carcinoma / Konovalova, N; Volkova, Lm; CODACCI PISANELLI, Giovanni; Seminara, Patrizia; Franchi, Fabrizio. - In: VOPROSY ONKOLOGII. - ISSN 0507-3758. - 46:(2000), pp. 438-441.
Effect of Ruboxil (nitroxyl derivative of daunomicin) on hepatic metastases of colorectal carcinoma
CODACCI PISANELLI, Giovanni;SEMINARA, Patrizia;FRANCHI, Fabrizio
2000
Abstract
Inhibition by ruboxyl, a nitroxyl derivative of daunorubicin, source preparation and 5-fluorouracil was compared in metastases of experimental colorectal carcinoma to murine liver. The indices of metastasis inhibition were 84.43 and 70%, respectively. In rats receiving the drugs by continuous intravenous infusion for 7 days, the number of metastases was reduced (ruboxyl--1.0 +/- 1.4; 5-fluorouracil 3.2 +/- 1.3.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
