PGE2 has been shown to be able to interfere with various lymphocyte and macrophage functions, but its effects on macrophage activation are still unclear. In this study, carried out on peritoneal macrophages obtained from healthy, tumour-bearing and Corynebacterium parvum-treated mice, we demonstrated that PGE2 is involved in the down-regulation of macrophage activation, but it cannot exert its inhibiting effect when macrophages are further stimulated with activating cytokines, such as IFN gamma and TNF alpha. Our findings provide new insight into how macrophage tumoricidal activity may be induced and maintained even in presence of significant levels of PGE2.
STIMULATION OF MACROPHAGES WITH IFN-GAMMA OR TNF-ALPHA SHUTS OFF THE SUPPRESSIVE EFFECT PLAYED BY PGE(2) / Zicari, Alessandra; Lipari, Marcella; DI RENZO, Livia Maria; Salerno, A; Losardo, A; Pontieri, Giuseppe. - In: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. - ISSN 0192-0561. - STAMPA. - 17:(1995), pp. 779-786. [10.1016/0192-0561(95)00045-4]
STIMULATION OF MACROPHAGES WITH IFN-GAMMA OR TNF-ALPHA SHUTS OFF THE SUPPRESSIVE EFFECT PLAYED BY PGE(2)
ZICARI, Alessandra;LIPARI, Marcella;DI RENZO, Livia Maria;PONTIERI, Giuseppe
1995
Abstract
PGE2 has been shown to be able to interfere with various lymphocyte and macrophage functions, but its effects on macrophage activation are still unclear. In this study, carried out on peritoneal macrophages obtained from healthy, tumour-bearing and Corynebacterium parvum-treated mice, we demonstrated that PGE2 is involved in the down-regulation of macrophage activation, but it cannot exert its inhibiting effect when macrophages are further stimulated with activating cytokines, such as IFN gamma and TNF alpha. Our findings provide new insight into how macrophage tumoricidal activity may be induced and maintained even in presence of significant levels of PGE2.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
