BackgroundProcollagen-III peptide (PIIINP) is a marker of fibrosis associated with increased cardiometabolic risk and progression of chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) and steatohepatitis; its association with type 2 diabetes mellitus (T2DM) has not been elucidated yet. The aim of this study was to investigate the relationship among circulating PIIINP levels, metabolic traits, and body fat distribution in subjects with T2DM with or without NAFLD.MethodsData from 62 T2DM subjects recruited in our diabetes outpatient clinics at Sapienza University of Rome, Italy, were analysed. Participants underwent metabolic and inflammatory profiling (CRP, TNF, IL-6, IL-8, WISP1, and adiponectin) and magnetic resonance imaging for diagnosing NAFLD on the basis of hepatic fat fraction (5.5%) and quantifying visceral and subcutaneous adipose tissue (AT) areas. Serum PIIINP was measured by human-PIIINP ELISA kits.ResultsHigher PIIINP levels correlated with greater BMI and visceral AT area and were associated with systemic signatures of AT-associated inflammationie, higher WISP-1, IL-8, and lower adiponectin levels; conversely, PIIINP did not differ significantly between T2DM patients with or without NAFLD and were not associated with hepatic fat fraction, Fatty Liver Index, FIB-4, or transaminases.ConclusionsElevated circulating PIIINP levels specifically identify T2DM individuals with AT expansion and systemic proinflammatory profile suggestive for AT dysfunction; our results point toward a new role of PIIINP as a marker of fibroinflammation in dysmetabolic conditions, likely related to AT expansion.

Procollagen-III peptide (PIIINP) is a marker of fibrosis associated with increased cardio-metabolic risk and progression of chronic liver diseases such as non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH); its association with type 2 diabetes mellitus has not been elucidated yet. Aim of this study was to investigate the relationship between circulating PIIINP levels, metabolic traits and body fat distribution in subjects with T2DM with or without NAFLD.

Procollagen-III peptide identifies adipose tissue-associated inflammation in type 2 diabetes with or without nonalcoholic liver disease / Barchetta, I; Cimini, F A; De Gioannis, R; Ciccarelli, G; Bertoccini, L; Lenzi, A; Baroni, M G; Cavallo, M G. - In: DIABETES/METABOLISM RESEARCH AND REVIEWS. - ISSN 1520-7552. - 34:5(2018), p. e2998. [10.1002/dmrr.2998]

Procollagen-III peptide identifies adipose tissue-associated inflammation in type 2 diabetes with or without nonalcoholic liver disease

Barchetta, I;Cimini, F A;Bertoccini, L;Lenzi, A;Baroni, M G;
2018

Abstract

BackgroundProcollagen-III peptide (PIIINP) is a marker of fibrosis associated with increased cardiometabolic risk and progression of chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) and steatohepatitis; its association with type 2 diabetes mellitus (T2DM) has not been elucidated yet. The aim of this study was to investigate the relationship among circulating PIIINP levels, metabolic traits, and body fat distribution in subjects with T2DM with or without NAFLD.MethodsData from 62 T2DM subjects recruited in our diabetes outpatient clinics at Sapienza University of Rome, Italy, were analysed. Participants underwent metabolic and inflammatory profiling (CRP, TNF, IL-6, IL-8, WISP1, and adiponectin) and magnetic resonance imaging for diagnosing NAFLD on the basis of hepatic fat fraction (5.5%) and quantifying visceral and subcutaneous adipose tissue (AT) areas. Serum PIIINP was measured by human-PIIINP ELISA kits.ResultsHigher PIIINP levels correlated with greater BMI and visceral AT area and were associated with systemic signatures of AT-associated inflammationie, higher WISP-1, IL-8, and lower adiponectin levels; conversely, PIIINP did not differ significantly between T2DM patients with or without NAFLD and were not associated with hepatic fat fraction, Fatty Liver Index, FIB-4, or transaminases.ConclusionsElevated circulating PIIINP levels specifically identify T2DM individuals with AT expansion and systemic proinflammatory profile suggestive for AT dysfunction; our results point toward a new role of PIIINP as a marker of fibroinflammation in dysmetabolic conditions, likely related to AT expansion.
2018
Procollagen-III peptide (PIIINP) is a marker of fibrosis associated with increased cardio-metabolic risk and progression of chronic liver diseases such as non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH); its association with type 2 diabetes mellitus has not been elucidated yet. Aim of this study was to investigate the relationship between circulating PIIINP levels, metabolic traits and body fat distribution in subjects with T2DM with or without NAFLD.
adipose tissue; fatty liver; fibrosis; inflammation; procollagen-III; type 2 diabetes
01 Pubblicazione su rivista::01a Articolo in rivista
Procollagen-III peptide identifies adipose tissue-associated inflammation in type 2 diabetes with or without nonalcoholic liver disease / Barchetta, I; Cimini, F A; De Gioannis, R; Ciccarelli, G; Bertoccini, L; Lenzi, A; Baroni, M G; Cavallo, M G. - In: DIABETES/METABOLISM RESEARCH AND REVIEWS. - ISSN 1520-7552. - 34:5(2018), p. e2998. [10.1002/dmrr.2998]
File allegati a questo prodotto
File Dimensione Formato  
Barchetta_Procollagen-III_2018.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 165.43 kB
Formato Adobe PDF
165.43 kB Adobe PDF   Contatta l'autore
Barchetta_postprint_Procollagen-III_2018.pdf

accesso aperto

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 441.77 kB
Formato Adobe PDF
441.77 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1076898
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 7
social impact