Three groups of innate lymphoid cells (ILCs) can be defined based on transcription factor requirements, cytokine production profiles, and roles in immunity. Given their strategic anatomical location into barrier tissues and the ability to rapidly produce cytokines and to cross-talk with other immune and non-immune cells, ILCs play fundamental functions in tissue homeostasis and regulation of immune responses. Several members of the chemokine family influence ILC tissue localization in the correct microenvironment by regulating their release from the bone marrow as well as their homing and retention in the tissues. In this review, we discuss the recent advances on how chemokine regulation of ILC tissue-positioning and functional interaction with other cells play essential roles in tissue-specific regulation of innate and adaptive immune responses.

Chemokine regulation of innate lymphoid cell tissue distribution and function / Soriani, Alessandra; Stabile, Helena; Gismondi, Angela; Santoni, Angela; Bernardini, Giovanni. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - STAMPA. - 42:(2018), pp. 47-55. [10.1016/j.cytogfr.2018.02.003]

Chemokine regulation of innate lymphoid cell tissue distribution and function

Soriani, Alessandra
Writing – Original Draft Preparation
;
Stabile, Helena
Writing – Original Draft Preparation
;
Gismondi, Angela
Writing – Review & Editing
;
Santoni, Angela
Writing – Review & Editing
;
Bernardini, Giovanni
Writing – Original Draft Preparation
2018

Abstract

Three groups of innate lymphoid cells (ILCs) can be defined based on transcription factor requirements, cytokine production profiles, and roles in immunity. Given their strategic anatomical location into barrier tissues and the ability to rapidly produce cytokines and to cross-talk with other immune and non-immune cells, ILCs play fundamental functions in tissue homeostasis and regulation of immune responses. Several members of the chemokine family influence ILC tissue localization in the correct microenvironment by regulating their release from the bone marrow as well as their homing and retention in the tissues. In this review, we discuss the recent advances on how chemokine regulation of ILC tissue-positioning and functional interaction with other cells play essential roles in tissue-specific regulation of innate and adaptive immune responses.
2018
Chemokine receptor; Chemokines; Innate lymphoid cells; Migration; Neurodegeneration; Tissue localization; Endocrinology, Diabetes and Metabolism; Immunology and Allergy; Immunology; Biochemistry, Genetics and Molecular Biology (all)
01 Pubblicazione su rivista::01a Articolo in rivista
Chemokine regulation of innate lymphoid cell tissue distribution and function / Soriani, Alessandra; Stabile, Helena; Gismondi, Angela; Santoni, Angela; Bernardini, Giovanni. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - STAMPA. - 42:(2018), pp. 47-55. [10.1016/j.cytogfr.2018.02.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1075939
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