Hereditary punctate keratoderma: clinical, pathology, treatment and follow-up

First described by Brown in 1971, punctate keratoderma (PK) 1 is a rare disorder, characterized by keratotic lesions on the palmo-plantar regions. Two types of PK have been described: the idiopathic and the hereditary variant.2 The idiopathic PK has been more commonly reported in the literature, often in association with neoplastic and non-neoplastic disorders.2-5 Contrariwise, few documented cases of hereditary PK have been reported in the literature supported by clinical and pathological pictures.2 A 66-year-old Caucasian man presented to our Institute with yellowish and asymptomatic keratotic papules, which had appeared gradually over the past 9 years on both palms without any involvement of the soles (Figure 1A, B).