Cancer stem cells (CSCs) are an uncommon subset of tumor cells capable of self-renewal, differentiating, and recreating the parental tumor when transplanted into the murine background. Over the past two decades, efforts toward understanding CSC biology culminated into identifying a set of signaling pathways sustaining "stemness". Nevertheless, while metabolic rewiring is nowadays considered a hallmark of cancer, no consensus has been reached on the metabolic features underlying the plastic nature of CSCs, which are capable of residing in a dormant state, and able to rapidly proliferate when the need to repopulate the tumor mass arises. An emerging concept in the field of CSC metabolism is that these cells are extremely reliant on the activity of enzymes involved in lipid metabolism, such as stearoyl-CoA desaturase 1 (SCD1) and 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR). Indeed, SCD1 and HMG-CoAR have been described as key factors for the correct function of a number of concatenated pathways involved in CSC fate decision, such as Hippo and Wnt. In the present review, we describe metabolic futures of CSCs with a special focus on lipid metabolism, which until now represents an underappreciated force in maintaining CSCs and an attractive therapeutic target.

Metabolic features of cancer stem cells. the emerging role of lipid metabolism / Mancini, Rita; Noto, Alessia; Pisanu, Maria Elena; De Vitis, Claudia; Maugeri-Saccà, Marcello; Ciliberto, Gennaro. - In: ONCOGENE. - ISSN 0950-9232. - ELETTRONICO. - 37:18(2018), pp. 1-12. [10.1038/s41388-018-0141-3]

Metabolic features of cancer stem cells. the emerging role of lipid metabolism

Mancini, Rita;Noto, Alessia;De Vitis, Claudia;
2018

Abstract

Cancer stem cells (CSCs) are an uncommon subset of tumor cells capable of self-renewal, differentiating, and recreating the parental tumor when transplanted into the murine background. Over the past two decades, efforts toward understanding CSC biology culminated into identifying a set of signaling pathways sustaining "stemness". Nevertheless, while metabolic rewiring is nowadays considered a hallmark of cancer, no consensus has been reached on the metabolic features underlying the plastic nature of CSCs, which are capable of residing in a dormant state, and able to rapidly proliferate when the need to repopulate the tumor mass arises. An emerging concept in the field of CSC metabolism is that these cells are extremely reliant on the activity of enzymes involved in lipid metabolism, such as stearoyl-CoA desaturase 1 (SCD1) and 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR). Indeed, SCD1 and HMG-CoAR have been described as key factors for the correct function of a number of concatenated pathways involved in CSC fate decision, such as Hippo and Wnt. In the present review, we describe metabolic futures of CSCs with a special focus on lipid metabolism, which until now represents an underappreciated force in maintaining CSCs and an attractive therapeutic target.
2018
cholesteryl ester accumulation; randomized presurgical trial; tumor-initiating cells; human-melanoma cells; breast-cancer; lactic-acid; oxidative-phosphorylation; opportunity neoadjuvant; mevalonate pathway; therapeutic target
01 Pubblicazione su rivista::01a Articolo in rivista
Metabolic features of cancer stem cells. the emerging role of lipid metabolism / Mancini, Rita; Noto, Alessia; Pisanu, Maria Elena; De Vitis, Claudia; Maugeri-Saccà, Marcello; Ciliberto, Gennaro. - In: ONCOGENE. - ISSN 0950-9232. - ELETTRONICO. - 37:18(2018), pp. 1-12. [10.1038/s41388-018-0141-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1072019
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