Lipid A aminoarabinosylation is invariably associated with colistin resistance inPseudomonas aeruginosa; however, the existence of alternative, aminoarabinosylation-independent colistin resistance mechanisms in this bacterium remained elusive. By combining reverse genetics with experimental evolution assays we demonstrate that a functional lipid A aminoarabinosylation pathway is critical for acquisition of colistin resistance in reference and clinicalP. aeruginosaisolates. This highlights lipid A aminoarabinosylation as a promising target for the design of colistin adjuvants againstP. aeruginosa.

Aminoarabinosylation of lipid A is critical for the development of colistin resistance in Pseudomonas aeruginosa / LO SCIUTO, Alessandra; Imperi, Francesco. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 62:3(2018), pp. 1-4. [10.1128/AAC.01820-17]

Aminoarabinosylation of lipid A is critical for the development of colistin resistance in Pseudomonas aeruginosa

LO SCIUTO, ALESSANDRA;Imperi, Francesco
2018

Abstract

Lipid A aminoarabinosylation is invariably associated with colistin resistance inPseudomonas aeruginosa; however, the existence of alternative, aminoarabinosylation-independent colistin resistance mechanisms in this bacterium remained elusive. By combining reverse genetics with experimental evolution assays we demonstrate that a functional lipid A aminoarabinosylation pathway is critical for acquisition of colistin resistance in reference and clinicalP. aeruginosaisolates. This highlights lipid A aminoarabinosylation as a promising target for the design of colistin adjuvants againstP. aeruginosa.
2018
Pseudomonas aeruginosa; LPS; lipid A; aminoarabinose; arn operon; colistin; resistance
01 Pubblicazione su rivista::01a Articolo in rivista
Aminoarabinosylation of lipid A is critical for the development of colistin resistance in Pseudomonas aeruginosa / LO SCIUTO, Alessandra; Imperi, Francesco. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 62:3(2018), pp. 1-4. [10.1128/AAC.01820-17]
File allegati a questo prodotto
File Dimensione Formato  
LoSciuto_Lipid_2018.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 274.67 kB
Formato Adobe PDF
274.67 kB Adobe PDF
losciuto_Lipid_2018.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 277.21 kB
Formato Adobe PDF
277.21 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1071370
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 18
social impact