The MultimodalImagingofNeurologicalDisorders(MINDView)projectaimstodevelopadedicated brain PositronEmissionTomography(PET)scannerwithsufficient resolutionandsensitivitytovisualize neurotransmitterpathwaysandtheirdisruptionsinmentaldisordersfordiagnosisandfollow-up treatment. ThePETsystemshouldbecompactandfullycompatiblewithaMagneticResonanceIma- ging (MRI)deviceinordertoallowitsoperationasaPETbraininsertinahybridimagingsetupwith most MRIscanners.Theproposeddesignwillenablethecurrently-installedMRIbasetobeeasily upgraded toPET/MRIsystems. The currentdesignforthePETinsertconsistsofa3-ringconfiguration with20modulesperringand an axial field ofviewof 15cmandageometricalapertureof 33 cmindiameter.Whencoupledtothe new headRadioFrequency(RF)coil,theinnerusablediameterofthecompletePET-RFcoilinsertis reduced to26cm.Twoscintillatorconfigurations havebeentested,namelya3-layerstaggeredarrayof LYSOwith1.5mmpixelsize,with3535 elements(6mmthicknesseach)andablack-paintedmono- lithic LYSOblockalsocoveringabout5050 mm2 activeareawith20mmthickness. LaboratorytestresultsassociatedwiththecurrentMINDViewPETmoduleconceptarepresentedin terms ofkeyparameters'optimization,suchasspatialandenergyresolution,sensitivityandDepthof Interaction(DOI)capability.Itwaspossibletoresolveallpixelelementsfromthethreescintillatorlayers with energyresolutionsasgoodas10%.Themonolithicscintillatorshowedaveragedetectorresolutions varyingfrom3.5mmintheentrancelayertobetterthan1.5mmnearthephotosensor,withaverage energy resolutionsofabout17%.
The MINDView brain PET detector, feasibility study based on SiPM arrays / González, Antonio J.; Majewski, Stan; Sánchez, Filomeno; Aussenhofer, Sebastian; Aguilar, Albert; Conde, Pablo; Hernández, Liczandro; Vidal, Luis F.; Pani, Roberto; Bettiol, Marco; Fabbri, Andrea; Bert, Julien; Visvikis, Dimitris; Jackson, Carl; Murphy, John; O'Neill, Kevin; Benlloch, Jose M.. - In: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. - ISSN 0168-9002. - 818:(2016), pp. 82-90. [10.1016/j.nima.2016.02.046]
The MINDView brain PET detector, feasibility study based on SiPM arrays
Pani, Roberto;Bettiol, Marco;
2016
Abstract
The MultimodalImagingofNeurologicalDisorders(MINDView)projectaimstodevelopadedicated brain PositronEmissionTomography(PET)scannerwithsufficient resolutionandsensitivitytovisualize neurotransmitterpathwaysandtheirdisruptionsinmentaldisordersfordiagnosisandfollow-up treatment. ThePETsystemshouldbecompactandfullycompatiblewithaMagneticResonanceIma- ging (MRI)deviceinordertoallowitsoperationasaPETbraininsertinahybridimagingsetupwith most MRIscanners.Theproposeddesignwillenablethecurrently-installedMRIbasetobeeasily upgraded toPET/MRIsystems. The currentdesignforthePETinsertconsistsofa3-ringconfiguration with20modulesperringand an axial field ofviewof 15cmandageometricalapertureof 33 cmindiameter.Whencoupledtothe new headRadioFrequency(RF)coil,theinnerusablediameterofthecompletePET-RFcoilinsertis reduced to26cm.Twoscintillatorconfigurations havebeentested,namelya3-layerstaggeredarrayof LYSOwith1.5mmpixelsize,with3535 elements(6mmthicknesseach)andablack-paintedmono- lithic LYSOblockalsocoveringabout5050 mm2 activeareawith20mmthickness. LaboratorytestresultsassociatedwiththecurrentMINDViewPETmoduleconceptarepresentedin terms ofkeyparameters'optimization,suchasspatialandenergyresolution,sensitivityandDepthof Interaction(DOI)capability.Itwaspossibletoresolveallpixelelementsfromthethreescintillatorlayers with energyresolutionsasgoodas10%.Themonolithicscintillatorshowedaveragedetectorresolutions varyingfrom3.5mmintheentrancelayertobetterthan1.5mmnearthephotosensor,withaverage energy resolutionsofabout17%.| File | Dimensione | Formato | |
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