Interferon (IFN) lambdas are important specific components of the mucosal innate immune response. The IFN lambda 4 (IFNL4) dinucleotide polymorphism (ΔG/TT) determines the IFN lambdas and related Interferon-stimulated genes activation, in HCV and other chronic infections. Our group first reported that IFN Lambda response was impaired in high-risk Human Papillomavirus (HPV) cervical infections and in precancerous lesions. Accordingly, we sought to evaluate the possible role of the IFNL4 polymorphism in determining HPV infection outcome. The ΔG/TT alleles were not differently distributed in 221 women with high- or low-risk HPV infection, with HPV infection clearance or persistence, and with abnormal cytology.
Interferon lambda4 polymorphism is not associated with human papillomavirus infection outcome / Cannella, Fabiana; Scagnolari, Carolina; Statzu, Maura; Sciandra, Ilaria; Recine, Nadia; D’Ettorre, Gabriella; Antonelli, Guido; Pierangeli, Alessandra. - In: VIRUS GENES. - ISSN 0920-8569. - STAMPA. - (2018). [10.1007/s11262-017-1527-y]
Interferon lambda4 polymorphism is not associated with human papillomavirus infection outcome
Cannella, Fabiana;Scagnolari, Carolina
;Statzu, Maura;Sciandra, Ilaria;Recine, NadiaMembro del Collaboration Group
;D’Ettorre, GabriellaMembro del Collaboration Group
;Antonelli, Guido;Pierangeli, Alessandra
2018
Abstract
Interferon (IFN) lambdas are important specific components of the mucosal innate immune response. The IFN lambda 4 (IFNL4) dinucleotide polymorphism (ΔG/TT) determines the IFN lambdas and related Interferon-stimulated genes activation, in HCV and other chronic infections. Our group first reported that IFN Lambda response was impaired in high-risk Human Papillomavirus (HPV) cervical infections and in precancerous lesions. Accordingly, we sought to evaluate the possible role of the IFNL4 polymorphism in determining HPV infection outcome. The ΔG/TT alleles were not differently distributed in 221 women with high- or low-risk HPV infection, with HPV infection clearance or persistence, and with abnormal cytology.File | Dimensione | Formato | |
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