Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer. By interacting with epigenetic regulators and by controlling chromatin topology, their misregulation may result in an aberrant regulation of gene expression that may contribute to tumorigenesis. Here, we review the functional role and mechanisms of action of lncRNAs implicated in the aberrant epigenetic regulation that has characterized cancer development and progression.

Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer / Morlando, Mariangela; Fatica, Alessandro. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - STAMPA. - 19:2(2018). [10.3390/ijms19020570]

Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer

Morlando, Mariangela
;
Fatica, Alessandro
2018

Abstract

Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer. By interacting with epigenetic regulators and by controlling chromatin topology, their misregulation may result in an aberrant regulation of gene expression that may contribute to tumorigenesis. Here, we review the functional role and mechanisms of action of lncRNAs implicated in the aberrant epigenetic regulation that has characterized cancer development and progression.
2018
cancer; chromatin; epigenetics; lncRNA
01 Pubblicazione su rivista::01a Articolo in rivista
Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer / Morlando, Mariangela; Fatica, Alessandro. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - STAMPA. - 19:2(2018). [10.3390/ijms19020570]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1068813
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