Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the "next generation" of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host's defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles.

CAR-T cell. the long and winding road to solid tumors / D'Aloia, MARIA MICHELA; Zizzari, ILARIA GRAZIA; Sacchetti, Benedetto; Pierelli, Luca; Alimandi, Maurizio. - In: CELL DEATH & DISEASE. - ISSN 2041-4889. - STAMPA. - 9:3(2018), pp. 1-12. [10.1038/s41419-018-0278-6]

CAR-T cell. the long and winding road to solid tumors

Maria Michela D’Aloia
Writing – Original Draft Preparation
;
Ilaria Grazia Zizzari
Formal Analysis
;
Benedetto Sacchetti
Software
;
Luca Pierelli
Conceptualization
;
Maurizio Alimandi
Writing – Original Draft Preparation
2018

Abstract

Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the "next generation" of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host's defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles.
File allegati a questo prodotto
File Dimensione Formato  
D-Aloia_Cell_2018.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.28 MB
Formato Adobe PDF
1.28 MB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1067709
Citazioni
  • ???jsp.display-item.citation.pmc??? 127
  • Scopus 216
  • ???jsp.display-item.citation.isi??? 223
social impact