In treating head and neck cancer (HNC), the objectives are provided for best functional results and minimal risk of serious complications. The choice of appropriate management depends primarily on specific site and stage of primary tumor at diagnosis. Radiation therapy (RT) with or without concomitant chemotherapy represents a classical treatment option. In this review, we provide an update of recent research strategies to counteract the existing damage caused by RT and highlight clinical trials currently in progress. We discuss the challenges in the evaluation of new stage system and RT-related toxicity onset. We mainly address the deficiencies and the advantages noted in the current treatment era.

Radiotherapy controversies and prospective in head and neck cancer: a literature-based critical review / De Felice, Francesca; Polimeni, Antonella; Valentini, Valentino; Brugnoletti, Orlando; Cassoni, Andrea; Greco, Antonio; De Vincentiis, Marco; Tombolini, Vincenzo. - In: NEOPLASIA. - ISSN 1522-8002. - ELETTRONICO. - 20:3(2018), pp. 227-232. [10.1016/j.neo.2018.01.002]

Radiotherapy controversies and prospective in head and neck cancer: a literature-based critical review

Francesca De Felice
Primo
;
Antonella Polimeni
Secondo
;
Valentino Valentini;Orlando Brugnoletti;Andrea Cassoni;Antonio Greco;Marco de Vincentiis
Penultimo
;
Vincenzo Tombolini
Ultimo
2018

Abstract

In treating head and neck cancer (HNC), the objectives are provided for best functional results and minimal risk of serious complications. The choice of appropriate management depends primarily on specific site and stage of primary tumor at diagnosis. Radiation therapy (RT) with or without concomitant chemotherapy represents a classical treatment option. In this review, we provide an update of recent research strategies to counteract the existing damage caused by RT and highlight clinical trials currently in progress. We discuss the challenges in the evaluation of new stage system and RT-related toxicity onset. We mainly address the deficiencies and the advantages noted in the current treatment era.
2018
squamous-cell carcinoma; intensity-modulated radiotherapy; nasopharyngeal carcinoma; radiation-therapy; alpha-emitters; osteoradionecrosis; volume; immunotherapy; chemotherapy; definition
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Radiotherapy controversies and prospective in head and neck cancer: a literature-based critical review / De Felice, Francesca; Polimeni, Antonella; Valentini, Valentino; Brugnoletti, Orlando; Cassoni, Andrea; Greco, Antonio; De Vincentiis, Marco; Tombolini, Vincenzo. - In: NEOPLASIA. - ISSN 1522-8002. - ELETTRONICO. - 20:3(2018), pp. 227-232. [10.1016/j.neo.2018.01.002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1066294
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