Background and Objectives. The pro-inflammatory cytokine interleukin (IL)-1 has been suggested to play a role in atherosclerosis. Several genetic polymorphisms have been described in the genes of the IL-1 cluster and associations with coronary artery disease (CAD) have been reported, although with contrasting results. Design and Methods. The associations of a variable number tandem repeat (86pb) polymorphism in intron 2 of interleukin-1 receptor antagonist (IL1-RA) and of the -511 C/T polymorphism of IL-1beta with the risk of CAD were studied. Three hundred and thirty-five case (CAD+) patients with angiographically documented CAD (stenosis >50% in at least one major coronary artery) were compared with 205 unrelated individuals free CAD signs at angiogram (CAD- controls). One hundred and two (30.5%) CAD+ patients had single-vessel disease (SVD) and 233 (69.5%) multiple-vessel disease (MVD). Results. There was no statistically significant difference in either genotype distribution or allele frequency of both IL-1 RA and IL-1beta-511 C/T polymorphisms between CAD(+) cases and CAD- controls. Moreover in multivariate analysis, adjusting for mutliple comparisons and confounding factors, no difference was found in IL-1 RA genotype distribution between patients with SVD or MVD. Interpretation and Conclusions. Our study does not support the association between IL-1 RA intron 2 VNTR and IL-1beta-511 C/T polymorphisms and the risk of CAD in individuals undergoing coronary angiography.
Interleukin-1 gene cluster polymorphisms and risk of coronary artery disease / B., Vohnout; A., Di Castelnuovo; R., Trotta; A., D'Orazio; Pannitteri, Gaetano; Montali, Anna; M. B., Donati; Arca, Marcello; L., Iacoviello. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 88:1(2003), pp. 54-60.
Interleukin-1 gene cluster polymorphisms and risk of coronary artery disease
PANNITTERI, Gaetano;MONTALI, Anna;ARCA, Marcello;
2003
Abstract
Background and Objectives. The pro-inflammatory cytokine interleukin (IL)-1 has been suggested to play a role in atherosclerosis. Several genetic polymorphisms have been described in the genes of the IL-1 cluster and associations with coronary artery disease (CAD) have been reported, although with contrasting results. Design and Methods. The associations of a variable number tandem repeat (86pb) polymorphism in intron 2 of interleukin-1 receptor antagonist (IL1-RA) and of the -511 C/T polymorphism of IL-1beta with the risk of CAD were studied. Three hundred and thirty-five case (CAD+) patients with angiographically documented CAD (stenosis >50% in at least one major coronary artery) were compared with 205 unrelated individuals free CAD signs at angiogram (CAD- controls). One hundred and two (30.5%) CAD+ patients had single-vessel disease (SVD) and 233 (69.5%) multiple-vessel disease (MVD). Results. There was no statistically significant difference in either genotype distribution or allele frequency of both IL-1 RA and IL-1beta-511 C/T polymorphisms between CAD(+) cases and CAD- controls. Moreover in multivariate analysis, adjusting for mutliple comparisons and confounding factors, no difference was found in IL-1 RA genotype distribution between patients with SVD or MVD. Interpretation and Conclusions. Our study does not support the association between IL-1 RA intron 2 VNTR and IL-1beta-511 C/T polymorphisms and the risk of CAD in individuals undergoing coronary angiography.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
