Aims Thromboxane A2 (TXA2) is a key mediator of platelet activation and aggregation, and an important mediator of platelet-induced coronary artery constriction. We sought to investigate whether baseline plasma levels of TXA2 are associated with coronary no-reflow after primary percutaneous coronary intervention (PPCI). Methods and results A total of 47 consecutive patients (age, 62.5 +/- 12.7; male sex, 76.6%) admitted to our hospital for a first ST-segment elevation myocardial infarction and undergoing PPCI within 12 h of onset of symptoms were enrolled. Admission TXA2 plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). Angiographic no-reflow was defined as a final TIMI flow of <= 2 or final TIMI flow of 3 with a myocardial blush grade of < 2, whereas ST-segment resolution from baseline value of <= 50% was used as ECG index of no-reflow. At multivariable analysis TXA2 plasma levels, endothelin-1 (ET-1) plasma levels, and left anterior descending coronary artery (LAD) as culprit vessel were significant predictors of angiographic no-reflow (P = 0.04), whereas TXA2 and ET-1 plasma levels were the only independent predictors of lack of ST-segment resolution (P = 0.013 and 0.04, respectively). Of note, TXA2 tertiles were independent predictors of both angiographic no-reflow and lack of ST-segment resolution (OR, 3.5; 95% CI, 1.1-11; P = 0.03 and OR, 3; 95% CI, 1.3-7; P = 0.01, respectively). Conclusion TXA2 is an independent indicator of no-reflow that occurs after PPCI. This observation may open new therapeutic opportunity in the setting of PPCI.

Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention / G., Niccoli; S., Giubilato; E., Russ; C., Spaziani; A., Leo; I., Porto; A. M., Leone; F., Burzotta; Riondino, Silvia; Pulcinelli, FABIO MARIA; L. M., Biasucci; F., Crea. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - STAMPA. - 29:15(2008), pp. 1843-1850. [10.1093/eurheartj/ehn325]

Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention

RIONDINO, Silvia;PULCINELLI, FABIO MARIA;
2008

Abstract

Aims Thromboxane A2 (TXA2) is a key mediator of platelet activation and aggregation, and an important mediator of platelet-induced coronary artery constriction. We sought to investigate whether baseline plasma levels of TXA2 are associated with coronary no-reflow after primary percutaneous coronary intervention (PPCI). Methods and results A total of 47 consecutive patients (age, 62.5 +/- 12.7; male sex, 76.6%) admitted to our hospital for a first ST-segment elevation myocardial infarction and undergoing PPCI within 12 h of onset of symptoms were enrolled. Admission TXA2 plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). Angiographic no-reflow was defined as a final TIMI flow of <= 2 or final TIMI flow of 3 with a myocardial blush grade of < 2, whereas ST-segment resolution from baseline value of <= 50% was used as ECG index of no-reflow. At multivariable analysis TXA2 plasma levels, endothelin-1 (ET-1) plasma levels, and left anterior descending coronary artery (LAD) as culprit vessel were significant predictors of angiographic no-reflow (P = 0.04), whereas TXA2 and ET-1 plasma levels were the only independent predictors of lack of ST-segment resolution (P = 0.013 and 0.04, respectively). Of note, TXA2 tertiles were independent predictors of both angiographic no-reflow and lack of ST-segment resolution (OR, 3.5; 95% CI, 1.1-11; P = 0.03 and OR, 3; 95% CI, 1.3-7; P = 0.01, respectively). Conclusion TXA2 is an independent indicator of no-reflow that occurs after PPCI. This observation may open new therapeutic opportunity in the setting of PPCI.
2008
acute myocardial infarction; no-reflow; platelets; primary percutaneous coronary intervention; thromboxane a2
01 Pubblicazione su rivista::01a Articolo in rivista
Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention / G., Niccoli; S., Giubilato; E., Russ; C., Spaziani; A., Leo; I., Porto; A. M., Leone; F., Burzotta; Riondino, Silvia; Pulcinelli, FABIO MARIA; L. M., Biasucci; F., Crea. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - STAMPA. - 29:15(2008), pp. 1843-1850. [10.1093/eurheartj/ehn325]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/106308
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 66
  • ???jsp.display-item.citation.isi??? 57
social impact