Gellan nanohydrogel and phospholipid vesicles were combined to incorporate baicalin in new self-assembling core-shell gellantransfersomes obtained by an easy, scalable method. The vesicles were small in size (similar to 107 nm) and monodispersed (P.I. <= 0.24), forming a viscous system (similar to 24 mPa/s) as compared to transfersomes (similar to 1.6 mPa/s), as confirmed by rheological studies. Gellan was anchored to the bilayer domains through cholesterol, and the polymer chains were distributed onto the outer surface of the bilayer, thus forming a core-shell structure, as suggested by SAXS analyses. The optimal carrier ability of core-shell gellan-transfersomes was established by the high deposition of baicalin in the skin (similar to 11% in the whole skin), especially in the deeper tissue (similar to 8% in the dermis). Moreover, their ability to improve baicalin efficacy in anti-inflammatory and skin repair tests was confirmed in vivo in mice, providing the complete skin restoration and inhibiting all the studied inflammatory markers.
Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin / Manconi, Maria; Manca, Maria Letizia; Caddeo, Carla; Valenti, Donatella; Cencetti, Claudia; Diez-Sales, Octavio; Nacher, Amparo; Mir-Palomo, Silvia; Terencio, Maria Carmen; Demurtas, Davide; Gomez-Fernandez, Juan Carmelo; Aranda, Francisco José; Fadda, Anna Maria; Matricardi, Pietro. - In: NANOMEDICINE. - ISSN 1549-9634. - STAMPA. - 14:2(2018), pp. 569-579. [10.1016/j.nano.2017.12.001]
Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin
Cencetti, Claudia;Matricardi, Pietro
2018
Abstract
Gellan nanohydrogel and phospholipid vesicles were combined to incorporate baicalin in new self-assembling core-shell gellantransfersomes obtained by an easy, scalable method. The vesicles were small in size (similar to 107 nm) and monodispersed (P.I. <= 0.24), forming a viscous system (similar to 24 mPa/s) as compared to transfersomes (similar to 1.6 mPa/s), as confirmed by rheological studies. Gellan was anchored to the bilayer domains through cholesterol, and the polymer chains were distributed onto the outer surface of the bilayer, thus forming a core-shell structure, as suggested by SAXS analyses. The optimal carrier ability of core-shell gellan-transfersomes was established by the high deposition of baicalin in the skin (similar to 11% in the whole skin), especially in the deeper tissue (similar to 8% in the dermis). Moreover, their ability to improve baicalin efficacy in anti-inflammatory and skin repair tests was confirmed in vivo in mice, providing the complete skin restoration and inhibiting all the studied inflammatory markers.File | Dimensione | Formato | |
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