Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subset
All1 gene at chromosome 11q23 is consistently altered in acute leukemias of early infancy / Cimino, Giuseppe; LO COCO, Francesco; Biondi, A; Elia, L; Luciano, A; Croce, Cm; Masera, G; Mandelli, Franco; Canaani, E.. - In: BLOOD. - ISSN 0006-4971. - 82:(1993), pp. 544-546.
All1 gene at chromosome 11q23 is consistently altered in acute leukemias of early infancy
CIMINO, Giuseppe;LO COCO, Francesco;MANDELLI, Franco;
1993
Abstract
Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subsetI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
