Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subset

All1 gene at chromosome 11q23 is consistently altered in acute leukemias of early infancy / Cimino, Giuseppe; LO COCO, Francesco; Biondi, A; Elia, L; Luciano, A; Croce, Cm; Masera, G; Mandelli, Franco; Canaani, E.. - In: BLOOD. - ISSN 0006-4971. - 82:(1993), pp. 544-546.

All1 gene at chromosome 11q23 is consistently altered in acute leukemias of early infancy

CIMINO, Giuseppe;LO COCO, Francesco;MANDELLI, Franco;
1993

Abstract

Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subset
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All1 gene at chromosome 11q23 is consistently altered in acute leukemias of early infancy / Cimino, Giuseppe; LO COCO, Francesco; Biondi, A; Elia, L; Luciano, A; Croce, Cm; Masera, G; Mandelli, Franco; Canaani, E.. - In: BLOOD. - ISSN 0006-4971. - 82:(1993), pp. 544-546.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/105945
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