Many reports indicate that nitric oxide (NO) could be involved in migraine without aura (MWA), an extremely diffuse clinical event. Since monocyte may be a relevant source of NO, we analysed monocyte activation in MWA patients, in a period in which they were free of symptoms. NO basal production by MWA peripheral monocytes was significantly higher than in healthy subjects (91.25+/-8.6 mu M/10 degrees cells vs. 22.6+/-3.2 mu M /10(6) cells). Interestingly, even the release of prostaglandin E-2 (PGE(2)), was higher in MWA patients than in healthy subjects (3137+/-320 pg/10 degrees cells vs. 1531+/-220 pg/10(6) cells). The incubation of monocytes from healthy subjects and MWA patients with N-nitro-L-arginine methyl ester caused a marked decrease of both NO and PGE(2) release. We hypothesise that NOS and cyclooxygenase pathways in monocytes are linked and are, in MWA patients, up-regulated, even in a symptoms-free period. NO and PGE(2) hyperproduction could therefore be involved in the neurovascular modifications leading to migraine attacks.
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|Titolo:||Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients|
|Data di pubblicazione:||2000|
|Appartiene alla tipologia:||01a Articolo in rivista|