Granzyme A (TSP-1) is a serine esterase expressed in cytotoxic T and natural killer (NK) cell lines. Its presence in in vivo primed T cells is disputed at present. Here we show that normal rat NK cells contain granzyme A in vivo and that its expression is augmented by their short-term in vitro treatment with IL 2. Granzyme A expression in a NK cell population with LAK activity has also been examined.
Granzyme A expression by normal rat NK cells in vivo and by IL-2-activated NK cells in vitro / Velotti, F; Palmieri, Gabriella; Morrone, Stefania; Piccoli, Mario; Frati, Luigi; Santoni, Angela. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - STAMPA. - 19:(1989), pp. 575-578. [10.1002/eji.1830190328]
Granzyme A expression by normal rat NK cells in vivo and by IL-2-activated NK cells in vitro
PALMIERI, Gabriella;MORRONE, Stefania;PICCOLI, Mario;FRATI, Luigi;SANTONI, Angela
1989
Abstract
Granzyme A (TSP-1) is a serine esterase expressed in cytotoxic T and natural killer (NK) cell lines. Its presence in in vivo primed T cells is disputed at present. Here we show that normal rat NK cells contain granzyme A in vivo and that its expression is augmented by their short-term in vitro treatment with IL 2. Granzyme A expression in a NK cell population with LAK activity has also been examined.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
