Inhaled nitric oxide (NO) is a selective pulmonary vasodilator in patients with end-stage cardiac failure. Preoperative high pulmonary Vascular resistence could modify early and late results after heart transplantation generally due to right-ventricular failure. Aim of this study was to assess pulmonary Vascular resistence variability following inhalation of NO by using a scintigraphic method. Our preliminary results suggest that inhaled NO in patients with end-stage heart failure redistributes blood away from apical regions and towards more basal and posterior segments, probably dilating blood vessels in ventilated but nonperfused zones. NO may represent a simple and reliable method to evaluate dynamic response of pulmonary vasculature.
Inhaled nitric oxide in patients with severe heart failure: changes in perfusional and ventilatory lung scintigraphy / Speziale, G; DE BIASE, Luciano; DE VINCENTIS, Giuseppe; Ierardi, M; LA FRANCESCA, S; Ruvolo, G; Scopinaro, F; Marino, B.. - In: JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY. - ISSN 0022-5223. - 44:1(1996), pp. 35-39. [10.1055/s-2007-1011980]
Inhaled nitric oxide in patients with severe heart failure: changes in perfusional and ventilatory lung scintigraphy
DE BIASE, Luciano;DE VINCENTIS, Giuseppe;
1996
Abstract
Inhaled nitric oxide (NO) is a selective pulmonary vasodilator in patients with end-stage cardiac failure. Preoperative high pulmonary Vascular resistence could modify early and late results after heart transplantation generally due to right-ventricular failure. Aim of this study was to assess pulmonary Vascular resistence variability following inhalation of NO by using a scintigraphic method. Our preliminary results suggest that inhaled NO in patients with end-stage heart failure redistributes blood away from apical regions and towards more basal and posterior segments, probably dilating blood vessels in ventilated but nonperfused zones. NO may represent a simple and reliable method to evaluate dynamic response of pulmonary vasculature.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.