A leading strategy in tissue engineering is the design of biomimetic scaffolds that stimulate the body's repair mechanisms through the recruitment of endogenous stem cells to sites of injury. Approaches that employ the use of chemoattractant gradients to guide tissue regeneration without external cell sources are favored over traditional cell-based therapies that have limited potential for clinical translation. Following this concept, bioactive scaffolds can be engineered to provide a temporally and spatially controlled release of biological cues, with the possibility to mimic the complex signaling patterns of endogenous tissue regeneration. Another effective way to regulate stem cell activity is to leverage the inherent chemotactic properties of extracellular matrix (ECM)-based materials to build versatile cell-instructive platforms. This review introduces the concept of endogenous stem cell recruitment, and provides a comprehensive overview of the strategies available to achieve effective cardiovascular and bone tissue regeneration. © 2017 Elsevier B.V.
Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration / Pacelli, Settimio; Basu, Sayantani; Whitlow, Jonathan; Chakravarti, Aparna; Acosta, Francisca; Varshney, Arushi; Modaresi, Saman; Berkland, Cory; Paul, Arghya. - In: ADVANCED DRUG DELIVERY REVIEWS. - ISSN 0169-409X. - ELETTRONICO. - 120:(2017), pp. 50-70. [10.1016/j.addr.2017.07.011]
Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration
Pacelli, Settimio;
2017
Abstract
A leading strategy in tissue engineering is the design of biomimetic scaffolds that stimulate the body's repair mechanisms through the recruitment of endogenous stem cells to sites of injury. Approaches that employ the use of chemoattractant gradients to guide tissue regeneration without external cell sources are favored over traditional cell-based therapies that have limited potential for clinical translation. Following this concept, bioactive scaffolds can be engineered to provide a temporally and spatially controlled release of biological cues, with the possibility to mimic the complex signaling patterns of endogenous tissue regeneration. Another effective way to regulate stem cell activity is to leverage the inherent chemotactic properties of extracellular matrix (ECM)-based materials to build versatile cell-instructive platforms. This review introduces the concept of endogenous stem cell recruitment, and provides a comprehensive overview of the strategies available to achieve effective cardiovascular and bone tissue regeneration. © 2017 Elsevier B.V.File | Dimensione | Formato | |
---|---|---|---|
Pacelli_Strategies_2017.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
3.08 MB
Formato
Adobe PDF
|
3.08 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.