The method based on the confidence limits of a regression straight line is applied to the linear portion of the calibration curve of a biosensor in order to determine the limit of detection. A practical application gives a detection limit of an ethanol biosensor greater than that calculated by using the method of the signal-to-noise-ratio, S/N= 3, but the value is more reliable because it accounts for the variability in the response at analyte additions. A simple approximation of the method is also presented.
A calibration-base method for the evaluation of the detection limit of an electrochemical biosensor / Irma, Lavagnini; Antiochia, Riccarda; Franco, Magno. - In: ELECTROANALYSIS. - ISSN 1040-0397. - STAMPA. - 19:11(2007), pp. 1227-1230. [10.1002/elan.200703847]
A calibration-base method for the evaluation of the detection limit of an electrochemical biosensor
ANTIOCHIA, RICCARDA;
2007
Abstract
The method based on the confidence limits of a regression straight line is applied to the linear portion of the calibration curve of a biosensor in order to determine the limit of detection. A practical application gives a detection limit of an ethanol biosensor greater than that calculated by using the method of the signal-to-noise-ratio, S/N= 3, but the value is more reliable because it accounts for the variability in the response at analyte additions. A simple approximation of the method is also presented.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
