Hypoxia-ischemia (H-I) constitutes the main phenomenon responsible for brain-blood barrier permeability modifications leading to cerebral vascular auto-regulation loss in newborns. Hypotension, cerebral ischemia, and reperfusion are the main events involved in vascular auto-regulation loss leading to cell death and tissue damage. Reperfusion could be critical since organ damage, particularly of the brain, may be amplified during this period. An exaggerated activation of vasoactive agents, of calcium mediated effects could be responsible for reperfusion injury (R-I), which, in turns, leads to cerebral hemorrhage and damage. These phenomena represent a common repertoire in newborns complicated by perinatal acute or chronic hypoxia treated by risky procedures such as mechanical ventilation, nitric oxide supplementation, brain cooling, and extracorporeal membrane oxygenation (ECMO). Despite accurate monitoring, the post-insult period is crucial, as clinical symptoms and standard monitoring parameters may be silent at a time when brain damage is already occurring and the therapeutic window for pharmacological intervention is limited. Therefore, the measurement of circulating biochemical markers of brain damage, such as vasoactive agents and nervous tissue peptides is eagerly awaited in clinical practice to detect high risk newborns. The present review is aimed at investigating the role of biochemical markers such as adrenomedullin, a vasoactive peptide; S100B, a calcium binding protein, activin A, a glycoprotein, in the cascade of events leading to I-R injury in newborns complicated by perinatal asphyxia.

New markers of neonatal neurology / Diego, Gazzolo; Raul, Abella; Marinoni, Emanuela; DI IORIO, Romolo; Giovanni Li, Volti; Fabio, Galvano; Alessandro, Frigiola; F., Temperini; Luca, Moresco; Micaela, Colivicchi; Miriam, Sabatini; Alberto, Ricotti; Maria Chiara, Strozzi; Sandro, Crivelli; Francesco Maria, Risso; A., Sannita; Pasquale, Florio. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-7058. - STAMPA. - 22:3(2009), pp. 57-61. (Intervento presentato al convegno 5th International Workshop on Neonatology - Present and Future of European Neonatology5th International Workshop on Neonatology - Present and Future of European Neonatology tenutosi a Cagliari, ITALYCagliari, ITALY nel OCT 29-31, 2009OCT 29-31, 2009) [10.1080/14767050903181468].

New markers of neonatal neurology

MARINONI, EMANUELA;DI IORIO, Romolo;
2009

Abstract

Hypoxia-ischemia (H-I) constitutes the main phenomenon responsible for brain-blood barrier permeability modifications leading to cerebral vascular auto-regulation loss in newborns. Hypotension, cerebral ischemia, and reperfusion are the main events involved in vascular auto-regulation loss leading to cell death and tissue damage. Reperfusion could be critical since organ damage, particularly of the brain, may be amplified during this period. An exaggerated activation of vasoactive agents, of calcium mediated effects could be responsible for reperfusion injury (R-I), which, in turns, leads to cerebral hemorrhage and damage. These phenomena represent a common repertoire in newborns complicated by perinatal acute or chronic hypoxia treated by risky procedures such as mechanical ventilation, nitric oxide supplementation, brain cooling, and extracorporeal membrane oxygenation (ECMO). Despite accurate monitoring, the post-insult period is crucial, as clinical symptoms and standard monitoring parameters may be silent at a time when brain damage is already occurring and the therapeutic window for pharmacological intervention is limited. Therefore, the measurement of circulating biochemical markers of brain damage, such as vasoactive agents and nervous tissue peptides is eagerly awaited in clinical practice to detect high risk newborns. The present review is aimed at investigating the role of biochemical markers such as adrenomedullin, a vasoactive peptide; S100B, a calcium binding protein, activin A, a glycoprotein, in the cascade of events leading to I-R injury in newborns complicated by perinatal asphyxia.
2009
activin a; adrenomedullin; brain damage; newborn; perinatal asphyxia; s100b
01 Pubblicazione su rivista::01a Articolo in rivista
New markers of neonatal neurology / Diego, Gazzolo; Raul, Abella; Marinoni, Emanuela; DI IORIO, Romolo; Giovanni Li, Volti; Fabio, Galvano; Alessandro, Frigiola; F., Temperini; Luca, Moresco; Micaela, Colivicchi; Miriam, Sabatini; Alberto, Ricotti; Maria Chiara, Strozzi; Sandro, Crivelli; Francesco Maria, Risso; A., Sannita; Pasquale, Florio. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-7058. - STAMPA. - 22:3(2009), pp. 57-61. (Intervento presentato al convegno 5th International Workshop on Neonatology - Present and Future of European Neonatology5th International Workshop on Neonatology - Present and Future of European Neonatology tenutosi a Cagliari, ITALYCagliari, ITALY nel OCT 29-31, 2009OCT 29-31, 2009) [10.1080/14767050903181468].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/103914
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