Intravaginal gemeprost and second-trimester pregnancy termination in the scarred uterus

Objective: To investigate the effectiveness and complication rate of intravaginal gemeprost, a prostaglandin E, analogue, for second-trimester pregnancy termination in women with a scarred uterus. Methods: Of 439 women undergoing induced abortion between the 13th and the 23rd week of pregnancy, 67 had a scarred uterus because of 1 or more cesarean sections or myornectomy. All women received a 1 mg dose of gemeprost intravaginally every 3 h, up to 5 times over 24 h. Those who did not respond received further cycles of gemeprost treatment. Results: The rate of successful abortions among women with uterine scars was not different from that observed in the nultiparous controls, but previously vaginal delivery was associated with a shorter induction to abortion interval. The rate of severe complications did not differ between the groups, and was about 1%. Conclusion: The rate of complications following intravaginal administration of a PGE, analogue for second - trimester pregnancy termination was similar in women with a scarred or unscarred uterus. (c) 2007 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.