Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate cartilage, where it favors chondrocyte survival and cartilage matrix mineralization. It was also shown to be highly expressed in differentiating osteoblasts and osteoclasts, in concomitance with expression of osteogenic markers and Runt-related transcription factor 2 and with the appearance of a mature phenotype. Galectin-3 is expressed also by osteocytes, though its function in these cells has not been fully elucidated. The effects of galectin-3 on bone cells were also investigated in galectin-3 null mice, further supporting its role in all stages of bone biology, from development to remodeling. Galectin-3 was also shown to act as a receptor for advanced glycation endproducts, which have been implicated in age-dependent and diabetes-associated bone fragility. Moreover, its regulatory role in inflammatory bone and joint disorders entitles galectin-3 as a possible therapeutic target. Finally, galectin-3 capacity to commit mesenchymal stem cells to the osteoblastic lineage and to favor transdifferentiation of vascular smooth muscle cells into an osteoblast-like phenotype open a new area of interest in bone and vascular pathologies.

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis / Iacobini, Carla; Fantauzzi, Claudia Blasetti; Pugliese, Giuseppe; Menini, Stefano. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 18:11(2017), pp. 1-20. [10.3390/ijms18112481]

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis

Iacobini, Carla
Primo
;
Fantauzzi, Claudia Blasetti
Secondo
;
Pugliese, Giuseppe
Penultimo
;
Menini, Stefano
Ultimo
2017

Abstract

Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate cartilage, where it favors chondrocyte survival and cartilage matrix mineralization. It was also shown to be highly expressed in differentiating osteoblasts and osteoclasts, in concomitance with expression of osteogenic markers and Runt-related transcription factor 2 and with the appearance of a mature phenotype. Galectin-3 is expressed also by osteocytes, though its function in these cells has not been fully elucidated. The effects of galectin-3 on bone cells were also investigated in galectin-3 null mice, further supporting its role in all stages of bone biology, from development to remodeling. Galectin-3 was also shown to act as a receptor for advanced glycation endproducts, which have been implicated in age-dependent and diabetes-associated bone fragility. Moreover, its regulatory role in inflammatory bone and joint disorders entitles galectin-3 as a possible therapeutic target. Finally, galectin-3 capacity to commit mesenchymal stem cells to the osteoblastic lineage and to favor transdifferentiation of vascular smooth muscle cells into an osteoblast-like phenotype open a new area of interest in bone and vascular pathologies.
2017
bone remodeling; galectin-3; osteoblasts; osteoclasts; vascular osteogenesis; catalysis; molecular biology; spectroscopy; computer science applications1707 computer vision and pattern recognition; physical and theoretical chemistry; organic chemistry; inorganic chemistry
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis / Iacobini, Carla; Fantauzzi, Claudia Blasetti; Pugliese, Giuseppe; Menini, Stefano. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 18:11(2017), pp. 1-20. [10.3390/ijms18112481]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1034974
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