OBJECTIVE - We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type I diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. RESEARCH DESIGN AND METHODS - Thirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 mu g/day calcitriol or placebo and followed-up for 2 years. RESULTS - At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point. CONCLUSIONS - At the doses used, calcitriol is ineffective in protecting beta-cell function in subjects (including children) with recent-onset type I diabetes and high C-peptide at diagnosis.
No protective effect of calcitriol on β-cell function in recent-onset type 1 diabetes: The IMDIAB XIII trial / C., Bizzarri; D., Pitocco; N., Napoli; E., Di Stasio; D., Maggi; S., Manfrini; C., Suraci; Cavallo, Maria Gisella; M., Cappa; G., Ghirlanda; P., Pozzilli; Group, Imdiab. - In: DIABETES CARE. - ISSN 0149-5992. - STAMPA. - 33:9(2010), pp. 1962-1963. [10.2337/dc10-0814]
No protective effect of calcitriol on β-cell function in recent-onset type 1 diabetes: The IMDIAB XIII trial
CAVALLO, Maria Gisella;
2010
Abstract
OBJECTIVE - We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type I diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. RESEARCH DESIGN AND METHODS - Thirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 mu g/day calcitriol or placebo and followed-up for 2 years. RESULTS - At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point. CONCLUSIONS - At the doses used, calcitriol is ineffective in protecting beta-cell function in subjects (including children) with recent-onset type I diabetes and high C-peptide at diagnosis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.