Recent neuroimaging studies have shown that alexithymia is characterized by functional alterations in different brain areas [e.g., posterior cingulate cortex (PCC)], during emotional/social tasks. However, only few data are available about alexithymic cortical networking features during resting state (RS). We have investigated the modifications of electroencephalographic (EEG) power spectra and EEG functional connectivity in the default mode network (DMN) in subjects with alexithymia. Eighteen subjects with alexithymia and eighteen subjects without alexithymia matched for age and gender were enrolled. EEG was recorded during 5 min of RS. EEG analyses were conducted by means of the exact Low Resolution Electric Tomography software (eLORETA). Compared to controls, alexithymic subjects showed a decrease of alpha power in the right PCC. In the connectivity analysis, compared to controls, alexithymic subjects showed a decrease of alpha connectivity between: (i) right anterior cingulate cortex and right PCC, (ii) right frontal lobe and right PCC, and (iii) right parietal lobe and right temporal lobe. Finally, mediation models showed that the association between alexithymia and EEG connectivity values was directed and was not mediated by psychopathology severity. Taken together, our results could reflect the neurophysiological substrate of some core features of alexithymia, such as the impairment in emotional awareness.

Default Mode Network alterations in alexithymia: An EEG power spectra and connectivity study / Imperatori, Claudio; Della Marca, Giacomo; Brunetti, Riccardo; Carbone, Giuseppe Alessio; Massullo, Chiara; Valenti, ENRICO MARIA; Amoroso, Noemi; Maestoso, Giulia; Contardi, Anna; Farina, Benedetto. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6:1(2017), p. 36653. [10.1038/srep36653]

Default Mode Network alterations in alexithymia: An EEG power spectra and connectivity study

Imperatori, Claudio
;
Brunetti, Riccardo;VALENTI, ENRICO MARIA;Contardi, Anna;
2017

Abstract

Recent neuroimaging studies have shown that alexithymia is characterized by functional alterations in different brain areas [e.g., posterior cingulate cortex (PCC)], during emotional/social tasks. However, only few data are available about alexithymic cortical networking features during resting state (RS). We have investigated the modifications of electroencephalographic (EEG) power spectra and EEG functional connectivity in the default mode network (DMN) in subjects with alexithymia. Eighteen subjects with alexithymia and eighteen subjects without alexithymia matched for age and gender were enrolled. EEG was recorded during 5 min of RS. EEG analyses were conducted by means of the exact Low Resolution Electric Tomography software (eLORETA). Compared to controls, alexithymic subjects showed a decrease of alpha power in the right PCC. In the connectivity analysis, compared to controls, alexithymic subjects showed a decrease of alpha connectivity between: (i) right anterior cingulate cortex and right PCC, (ii) right frontal lobe and right PCC, and (iii) right parietal lobe and right temporal lobe. Finally, mediation models showed that the association between alexithymia and EEG connectivity values was directed and was not mediated by psychopathology severity. Taken together, our results could reflect the neurophysiological substrate of some core features of alexithymia, such as the impairment in emotional awareness.
2017
EEG; Power spectra; Functional Connectivity; Alexithymia
01 Pubblicazione su rivista::01a Articolo in rivista
Default Mode Network alterations in alexithymia: An EEG power spectra and connectivity study / Imperatori, Claudio; Della Marca, Giacomo; Brunetti, Riccardo; Carbone, Giuseppe Alessio; Massullo, Chiara; Valenti, ENRICO MARIA; Amoroso, Noemi; Maestoso, Giulia; Contardi, Anna; Farina, Benedetto. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6:1(2017), p. 36653. [10.1038/srep36653]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1033275
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