The 8th edition of AJCC/TNM staging system for differentiated thyroid cancer (DTC) has recently been published. The aim of this study was to compare AJCC/TNM staging 7th and 8th edition in terms of tumor stage distribution in a multicenter, consecutive and prospective cohort of newly diagnosed DTC collected in a web-based observational database. Additional information concerning the extent of minimal extrathyroidal extension was collected. A cohort of 1765 DTC patients (76% females, median age 48 years, 94% papillary histotype) was analyzed. Younger patients (<45 years or <55 years according to 7th and 8th edition, respectively) were in stage II (presence of distant metastases) in 2% of the cases with both classifications. According to TNM 7th edition in patients aged ≥45 years (N=1067), stage distribution was: stage I 595 (56%), stage II 85 (8%), stage III 283 (26%), and stage IV 104 (10%). According to TNM 8th edition in patients aged ≥55 years (N=615) was: stage I 391 (64%), II 193 (31%), III 15 (2%) and IV 16 (3%). The 27% of the patients were downstaged with TNM 8th edition. The majority of newly diagnosed DTC patients are in low-risk stages. An important downstaging is observed applying TNM 8th edition.

8th edition of AJCC/TNM staging system of thyroid cancer: what to expect (ITCO#2) / Lamartina, Livia; Grani, Giorgio; Arvat, Emanuela; Nervo, Alice; Zatelli, Maria Chiara; Rossi, Roberta; Puxeddu, Efisio; Morelli, Silvia; Torlontano, Massimo; Massa, Michela; Bellantone, Rocco; Pontecorvi, Alfredo; Montesano, Teresa; Pagano, Loredana; Daniele, Lorenzo; Fugazzola, Laura; Ceresini, Graziano; Bruno, Rocco; Rossetto, Ruth; Tumino, Salvatore; Centanni, Marco; Meringolo, Domenico; Castagna, Maria Grazia; Salvatore, Domenico; Nicolucci, Antonio; Lucisano, Giuseppe; Filetti, Sebastiano; Durante, Cosimo. - In: ENDOCRINE-RELATED CANCER. - ISSN 1351-0088. - STAMPA. - 25:3(2018), pp. L7-L11. [10.1530/ERC-17-0453]

8th edition of AJCC/TNM staging system of thyroid cancer: what to expect (ITCO#2)

Lamartina, Livia
Co-primo
;
Grani, Giorgio
Co-primo
;
Montesano, Teresa;Centanni, Marco;Filetti, Sebastiano
Penultimo
;
Durante, Cosimo
Ultimo
2018

Abstract

The 8th edition of AJCC/TNM staging system for differentiated thyroid cancer (DTC) has recently been published. The aim of this study was to compare AJCC/TNM staging 7th and 8th edition in terms of tumor stage distribution in a multicenter, consecutive and prospective cohort of newly diagnosed DTC collected in a web-based observational database. Additional information concerning the extent of minimal extrathyroidal extension was collected. A cohort of 1765 DTC patients (76% females, median age 48 years, 94% papillary histotype) was analyzed. Younger patients (<45 years or <55 years according to 7th and 8th edition, respectively) were in stage II (presence of distant metastases) in 2% of the cases with both classifications. According to TNM 7th edition in patients aged ≥45 years (N=1067), stage distribution was: stage I 595 (56%), stage II 85 (8%), stage III 283 (26%), and stage IV 104 (10%). According to TNM 8th edition in patients aged ≥55 years (N=615) was: stage I 391 (64%), II 193 (31%), III 15 (2%) and IV 16 (3%). The 27% of the patients were downstaged with TNM 8th edition. The majority of newly diagnosed DTC patients are in low-risk stages. An important downstaging is observed applying TNM 8th edition.
cancer staging; risk stratification; prospective study; precision medicine; cancer management; differentiated thyroid cancer
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8th edition of AJCC/TNM staging system of thyroid cancer: what to expect (ITCO#2) / Lamartina, Livia; Grani, Giorgio; Arvat, Emanuela; Nervo, Alice; Zatelli, Maria Chiara; Rossi, Roberta; Puxeddu, Efisio; Morelli, Silvia; Torlontano, Massimo; Massa, Michela; Bellantone, Rocco; Pontecorvi, Alfredo; Montesano, Teresa; Pagano, Loredana; Daniele, Lorenzo; Fugazzola, Laura; Ceresini, Graziano; Bruno, Rocco; Rossetto, Ruth; Tumino, Salvatore; Centanni, Marco; Meringolo, Domenico; Castagna, Maria Grazia; Salvatore, Domenico; Nicolucci, Antonio; Lucisano, Giuseppe; Filetti, Sebastiano; Durante, Cosimo. - In: ENDOCRINE-RELATED CANCER. - ISSN 1351-0088. - STAMPA. - 25:3(2018), pp. L7-L11. [10.1530/ERC-17-0453]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1033147
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