An elevateci heart rate (HR) is an independent risk factor lor mor tality and morbidity in patients with acute heart failure. Pharmacologic inhibition of the l(f) current provides the opportunity of pure HR reduction, wh1ch has been associateci with anti-ischemic efficacy w1thout any effect on haemodynamic or rny ocardial contractility. SHIFT trial has evaluated /vabradine benefits in heart failure patients showing a significant decrease in the composite rate of card,ovascular death or heart-failure hosp1talization.
Our data suggest that, in patients with acute ischemie heart fail ure, /vabradine is effective for c.ontrolling the heart rate as well as for clinica! and l1aemodynamic recovery. The FC control, without any influence on BP values, im proves the outcorne of these patients. preventing the further deterioration of leh ventricular funclion
Clinical and haemodynamic effects of Ivabradine in patients with acute ischemic heart failure / Barilla', F.; Paravati, V.; Gaudio, C.; Torromeo, C.; Pannitteri, G; Petrini, N.. - In: EUROPEAN HEART JOURNAL SUPPLEMENTS. - ISSN 1554-2815. - STAMPA. - (2016), pp. 1330-1330.
Clinical and haemodynamic effects of Ivabradine in patients with acute ischemic heart failure
BARILLA', F.;PARAVATI, V.;GAUDIO, C.;TORROMEO, C.;PANNITTERI, G;Petrini, N.
2016
Abstract
An elevateci heart rate (HR) is an independent risk factor lor mor tality and morbidity in patients with acute heart failure. Pharmacologic inhibition of the l(f) current provides the opportunity of pure HR reduction, wh1ch has been associateci with anti-ischemic efficacy w1thout any effect on haemodynamic or rny ocardial contractility. SHIFT trial has evaluated /vabradine benefits in heart failure patients showing a significant decrease in the composite rate of card,ovascular death or heart-failure hosp1talization.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
