Background: A number of recent studies underline the importance of vitamin D in the pathogenesis of Type 1 diabetes (T1D). Aims: The aim of this study was to investigate whether supplementation with the active form of vitamin D (calcitriol) in subjects with recent-onset T1D protects residual pancreatic β-cell function and improves glycaemic control (HbA1c and insulin requirement). Methods: In this open-label randomized trial, 70 subjects with recent-onset T1D, mean age 13.6 years ± 7.6 SD were randomized to calcitriol (0.25 μg on alternate days) or nicotinamide (25 mg/kg daily) and followed up for 1 year. Intensive insulin therapy was implemented with three daily injections of regular insulin + NPH insulin at bedtime. Results: No significant differences were observed between calcitriol and nicotinamide groups in respect of baseline/stimulated C-peptide or HbA1c 1 year after diagnosis, but the insulin dose at 3 and 6 months was significantly reduced in the calcitriol group. Conclusions: At the dosage used, calcitriol has a modest effect on residual pancreatic β-cell function and only temporarily reduces the insulin dose. © 2006 The Authors.

The effects of calcitriol and nicotinamide on residual pancreatic beta-cell function in patients with recent-onset Type 1 diabetes (IMDIAB XI) / D., Pitocco; A., Crino; E., Di Stasio; S., Manfrini; C., Guglielmi; S., Spera; G., Beretta Anguissola; N., Visalli; C., Suraci; M. C., Matteoli; I. P., Patera; Cavallo, Maria Gisella; C., Bizzarri; P., Pozzilli; Group, Imdiab. - In: DIABETIC MEDICINE. - ISSN 0742-3071. - 23:8(2006), pp. 920-923. [10.1111/j.1464-5491.2006.01921.x]

The effects of calcitriol and nicotinamide on residual pancreatic beta-cell function in patients with recent-onset Type 1 diabetes (IMDIAB XI).

CAVALLO, Maria Gisella;
2006

Abstract

Background: A number of recent studies underline the importance of vitamin D in the pathogenesis of Type 1 diabetes (T1D). Aims: The aim of this study was to investigate whether supplementation with the active form of vitamin D (calcitriol) in subjects with recent-onset T1D protects residual pancreatic β-cell function and improves glycaemic control (HbA1c and insulin requirement). Methods: In this open-label randomized trial, 70 subjects with recent-onset T1D, mean age 13.6 years ± 7.6 SD were randomized to calcitriol (0.25 μg on alternate days) or nicotinamide (25 mg/kg daily) and followed up for 1 year. Intensive insulin therapy was implemented with three daily injections of regular insulin + NPH insulin at bedtime. Results: No significant differences were observed between calcitriol and nicotinamide groups in respect of baseline/stimulated C-peptide or HbA1c 1 year after diagnosis, but the insulin dose at 3 and 6 months was significantly reduced in the calcitriol group. Conclusions: At the dosage used, calcitriol has a modest effect on residual pancreatic β-cell function and only temporarily reduces the insulin dose. © 2006 The Authors.
2006
nicotinamide; type 1 diabetes; calcitriol
01 Pubblicazione su rivista::01a Articolo in rivista
The effects of calcitriol and nicotinamide on residual pancreatic beta-cell function in patients with recent-onset Type 1 diabetes (IMDIAB XI) / D., Pitocco; A., Crino; E., Di Stasio; S., Manfrini; C., Guglielmi; S., Spera; G., Beretta Anguissola; N., Visalli; C., Suraci; M. C., Matteoli; I. P., Patera; Cavallo, Maria Gisella; C., Bizzarri; P., Pozzilli; Group, Imdiab. - In: DIABETIC MEDICINE. - ISSN 0742-3071. - 23:8(2006), pp. 920-923. [10.1111/j.1464-5491.2006.01921.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/102991
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