There is growing research interest for the role of genetic and epigenetic factors in the etiopathogenesis of Hashimoto's Thyroiditis (HT). HT is an organ-specific autoimmune thyroid disease (AITD) accounting for most cases of clinical hypothyroidism and in which both cellular and humoral immunity have a role in the pathogenesis. HT is characterized by diffuse goiter supported by thyroid-specific autoantibodies and lymphoid infiltration of the thyroid gland including T and B cells [1]. Although rare before the 1950s, HT prevalence has consistently increased over the last years; it exhibits a strong female preponderance and highest incidence in white individuals and becomes more common with advancing age [2]. HT can increase the risk of thyroid cancer; the association between HT and papillary thyroid carcinoma has recently been re-evaluated and proposed on the basis of fine-needle aspiration cytology

New insights into the etiopathogenesis of Hashimoto's Thyroiditis: the role of genetics and epigenetics / Ralli, Massimo; DE VIRGILIO, Armando; Artico, Marco; Longo, Lucia; DE VINCENTIIS, Marco; Greco, Antonio. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - ELETTRONICO. - 17:10(2018), pp. 1065-1066. [10.1016/j.autrev.2018.05.004]

New insights into the etiopathogenesis of Hashimoto's Thyroiditis: the role of genetics and epigenetics

Massimo Ralli
Primo
;
Armando De Virgilio
Secondo
;
Marco Artico;Lucia Longo;Marco de Vincentiis
Penultimo
;
Antonio Greco
Ultimo
2018

Abstract

There is growing research interest for the role of genetic and epigenetic factors in the etiopathogenesis of Hashimoto's Thyroiditis (HT). HT is an organ-specific autoimmune thyroid disease (AITD) accounting for most cases of clinical hypothyroidism and in which both cellular and humoral immunity have a role in the pathogenesis. HT is characterized by diffuse goiter supported by thyroid-specific autoantibodies and lymphoid infiltration of the thyroid gland including T and B cells [1]. Although rare before the 1950s, HT prevalence has consistently increased over the last years; it exhibits a strong female preponderance and highest incidence in white individuals and becomes more common with advancing age [2]. HT can increase the risk of thyroid cancer; the association between HT and papillary thyroid carcinoma has recently been re-evaluated and proposed on the basis of fine-needle aspiration cytology
2018
Hashimoto's Thyroiditis; epigenetics; genetics
01 Pubblicazione su rivista::01f Lettera, Nota
New insights into the etiopathogenesis of Hashimoto's Thyroiditis: the role of genetics and epigenetics / Ralli, Massimo; DE VIRGILIO, Armando; Artico, Marco; Longo, Lucia; DE VINCENTIIS, Marco; Greco, Antonio. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - ELETTRONICO. - 17:10(2018), pp. 1065-1066. [10.1016/j.autrev.2018.05.004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1029554
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