Allogeneic hematopoietic cell transplantation represents an important therapy for certain malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a major cause of mortality and morbidity. The search for agents that can efficiently suppress GVHD has been going on for more than half a century. GVHD is particularly strong in xenogeneic donor-recipient combinations, given the unlimited number of potentially immunogenic antigens donor lymphocytes encounter in the host. Using a hunonobese diabetic/severe combined immunodeficiency (hu-NOD/SCID) gamma-null model of xenogeneic GVHD, we have demonstrated that treatment with recombinant immunoglobulin-like transcript 3-Fc protein induces the differentiation of CD8(+) T suppressor cells and blocks the cellular and humoral arm of the GVH reaction. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc / George, Vlad; Michael B., Stokes; Zhuoru, Liu; Chih Chao, Chang; Hugo, Sondermeijer; Elena R., Vasilescu; Adriana I., Colovai; Berloco, Pasquale Bartolomeo; Vivette D., D'Agati; Lloyd, Ratner; Cortesini, Raffaello; Nicole Suciu, Foca. - In: HUMAN IMMUNOLOGY. - ISSN 0198-8859. - 70:9(2009), pp. 663-669. [10.1016/j.humimm.2009.06.001]
Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc
BERLOCO, Pasquale Bartolomeo;CORTESINI, Raffaello;
2009
Abstract
Allogeneic hematopoietic cell transplantation represents an important therapy for certain malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a major cause of mortality and morbidity. The search for agents that can efficiently suppress GVHD has been going on for more than half a century. GVHD is particularly strong in xenogeneic donor-recipient combinations, given the unlimited number of potentially immunogenic antigens donor lymphocytes encounter in the host. Using a hunonobese diabetic/severe combined immunodeficiency (hu-NOD/SCID) gamma-null model of xenogeneic GVHD, we have demonstrated that treatment with recombinant immunoglobulin-like transcript 3-Fc protein induces the differentiation of CD8(+) T suppressor cells and blocks the cellular and humoral arm of the GVH reaction. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
