Mastocytosis can be associated with other clonal or non-clonal hematologic diseases as well as a variety of non-hematologic malignancies. A 75-year-old Caucasian male patient was referred to us with a 5-month history of neutrophilic leukocytosis and mild splenomegaly. He had developed a cutaneous melanoma sixteen years ago. According to the clinical and pathological features, a final diagnosis of systemic mastocytosis was established. The patient started treatment with interferon-α at a dose of 3 MIU/day, combined with low doses of prednisone. We observed a rapid disappearance of symptoms. Unfortunately, after 3 months a diagnosis of pancreatic adenocarcinoma was established. A review of the literature suggests that mastocytes could have a pivotal role in several malignancies. Different chemokines, mitogenic factors, chemical mediators of inflammation, and specific gene mutations could explain the association between mastocytosis and other hematologic and non-hematologic disorders.

Mast cell disorders, melanoma and pancreatic carcinoma: from a clinical observation to a brief review of the literature / Paolino, Giovanni; Belmonte, Maria; Trasarti, Stefania; Santopietro, Michelina; Bizzoni, Luisa; Riminucci, Mara; Cardarelli, Luisa; Iannella, Emilia; Albanesi, Marcello; Moliterni, Elisa; Didona, Dario; Calvieri, Stefano; Foà, Robin; Giona, Fiorina. - In: ACTA DERMATOVENEROLOGICA CROATICA. - ISSN 1330-027X. - 25:2(2017), pp. 112-119.

Mast cell disorders, melanoma and pancreatic carcinoma: from a clinical observation to a brief review of the literature

Paolino, Giovanni
Primo
;
Santopietro, Michelina;BIZZONI, LUISA;Riminucci, Mara;IANNELLA, EMILIA;Moliterni, Elisa;Calvieri, Stefano;Foà, Robin
Penultimo
;
Giona, Fiorina
Ultimo
2017

Abstract

Mastocytosis can be associated with other clonal or non-clonal hematologic diseases as well as a variety of non-hematologic malignancies. A 75-year-old Caucasian male patient was referred to us with a 5-month history of neutrophilic leukocytosis and mild splenomegaly. He had developed a cutaneous melanoma sixteen years ago. According to the clinical and pathological features, a final diagnosis of systemic mastocytosis was established. The patient started treatment with interferon-α at a dose of 3 MIU/day, combined with low doses of prednisone. We observed a rapid disappearance of symptoms. Unfortunately, after 3 months a diagnosis of pancreatic adenocarcinoma was established. A review of the literature suggests that mastocytes could have a pivotal role in several malignancies. Different chemokines, mitogenic factors, chemical mediators of inflammation, and specific gene mutations could explain the association between mastocytosis and other hematologic and non-hematologic disorders.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1023634
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