Background: Multislice computed tomography (MSCT) increased detection of solitary pulmonary nodules (SPNs), changing the management based on radiological and clinical factors. When 18-fluorine fluorodeoxyglucose positron emission tomography combined with computed tomography (18F-FDG-PET/CT) was considered for the evaluation of nodules, the maximum standardized uptake value (SUVmax) more than 2.5 is used frequently as a cut off for malignancy. The purpose of this study is to evaluate SUVmax PET/CT and pulmonary attenuation patterns at MSCT in patients with SPN according to morphological and pathological characteristics of the lesion. Methods: A retrospective study on 1,592 SPN patients was carried out following approval by the Italian Registry of VATS Lobectomies. Results: All patients underwent VATS lobectomy. On histologic examination, 98.1% had primary or second metachronous primary lung cancers. In addition, 10.7% presented occult lymph node metastases (pN1 or pN2) on histological examination. Nodule attenuation on CT was associated with the histology of the lesion (p= 0.030); in particular, pure ground glass opacities (pGGOs) and partially solid nodules were related to adenocarcinomatous histotypes. Conversely, a significant relationship between SUVmax and age, nodule size, pathological node status (pN) was found (P=0.007, P=0.000 and P=0.002 respectively). Conclusions: Nodule attenuation can predict the histology of the lesion whereas SUVmax may relate to the propensity to lymph node metastases. Keywords: Solitary pulmonary nodule (SPN); maximum standardized uptake value; ground glass opacities; lymph node metastases; lung adenocarcinoma

Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: Our experience on 1,592 patients / Divisi, Duilio; Barone, Mirko; Bertolaccini, Luca; Rocco, Gaetano; Solli, Piergiorgio; Crisci, Roberto; Italian Vats, Group; Ampollini, Luca; Alloisio, Marco; Andreetti, Claudio; Amore, Dario; Baietto, Guido; Bandiera, Alessandro; Benato, Cristiano; Benetti, Diego; Benvenuti, Mauro; Bertani, Alessandro; Bortolotti, Luigi; Bottoni, Edoardo; Camplese, Pierpaolo; Carbognani, Paolo; Cardillo, Giuseppe; Carleo, Francesco; Casadio, Caterina; Cavallesco, Giorgio; Curcio, Carlo; Denegri, Andrea; Di Rienzo, Gaetano; Dolci, Giampiero; Droghetti, Andrea; Gasparri, Roberto; Ghisalberti, Marco; Gonfiotti, Alessandro; Guerrera, Francesco; Imperatori, Andrea; Infante, Maurizio; Lausi, Paolo; Londero, Francesco; Lopez, Camillo; Luzzi, Luca; Maineri, Paola; Maniscalco, Pio; Marulli, Giuseppe; Monteverde, Marco; Morelli, Angelo; Mucilli, Felice; Natali, Pamela; Negri, Giampiero; Nicotra, Samuele; Nosotti, Mario; Perkmann, Reinhold; Poggi, Camilla; Puma, Francesco; Refai, Mayed; Rinaldo, Alessandro; Rizzardi, Giovanna; Rosso, Lorenzo; Rotolo, Nicola; Russo, Emanuele; Sabatini, Armando; Spaggiari, Lorenzo; Stefani, Alessandro; Stella, Franco; Terzi, Alberto; Torre, Massimo; Vinci, Damiano; Viti, Andrea; Voltolini, Luca; Zaraca, Francesco. - In: JOURNAL OF THORACIC DISEASE. - ISSN 2072-1439. - 9:8(2017), pp. 2551-2559. [10.21037/jtd.2017.06.124]

Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: Our experience on 1,592 patients

Poggi, Camilla
Membro del Collaboration Group
;
2017

Abstract

Background: Multislice computed tomography (MSCT) increased detection of solitary pulmonary nodules (SPNs), changing the management based on radiological and clinical factors. When 18-fluorine fluorodeoxyglucose positron emission tomography combined with computed tomography (18F-FDG-PET/CT) was considered for the evaluation of nodules, the maximum standardized uptake value (SUVmax) more than 2.5 is used frequently as a cut off for malignancy. The purpose of this study is to evaluate SUVmax PET/CT and pulmonary attenuation patterns at MSCT in patients with SPN according to morphological and pathological characteristics of the lesion. Methods: A retrospective study on 1,592 SPN patients was carried out following approval by the Italian Registry of VATS Lobectomies. Results: All patients underwent VATS lobectomy. On histologic examination, 98.1% had primary or second metachronous primary lung cancers. In addition, 10.7% presented occult lymph node metastases (pN1 or pN2) on histological examination. Nodule attenuation on CT was associated with the histology of the lesion (p= 0.030); in particular, pure ground glass opacities (pGGOs) and partially solid nodules were related to adenocarcinomatous histotypes. Conversely, a significant relationship between SUVmax and age, nodule size, pathological node status (pN) was found (P=0.007, P=0.000 and P=0.002 respectively). Conclusions: Nodule attenuation can predict the histology of the lesion whereas SUVmax may relate to the propensity to lymph node metastases. Keywords: Solitary pulmonary nodule (SPN); maximum standardized uptake value; ground glass opacities; lymph node metastases; lung adenocarcinoma
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1021862
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