The gut microbiota is involved in the regulation of cognition, mood, anxiety, and pain, and can impact cognitive functions by producing neuroactive substances or releasing bacterial by-products and metabolites. No information is available on the effects of a probiotic supplementation on brain function of HIV+ subjects. In light of the above considerations, we performed a pilot study in cART-treated HIV-1-positive patients with long-term virologic suppression. The aims were to analyze the effect of high-concentration multistrain probiotic supplementation (Vivomixx®; Visbiome®) on several neurocognitive abilities and to evaluate the safety of this supplementation.
A pilot study on the effects of probiotic supplementation on neuropsychological performance and microRNA-29a-c levels in antiretroviral-treated HIV-1-infected patients / Ceccarelli, G., Fratino, M., Selvaggi, C., Giustini, N., Serafino, S., Schietroma, I., Corano Scheri, G., Pavone, P., Passavanti, G., Alunni Fegatelli, D., Mezzaroma, I., Antonelli, G., Vullo, V., Scagnolari, C., D'Ettorre, G.. - In: BRAIN AND BEHAVIOR. - ISSN 2162-3279. - ELETTRONICO. - 7:8(2017), p. e00756. [10.1002/brb3.756]
A pilot study on the effects of probiotic supplementation on neuropsychological performance and microRNA-29a-c levels in antiretroviral-treated HIV-1-infected patients
Ceccarelli, Giancarlo;Fratino, Mariangela;Selvaggi, Carla;Giustini, Noemi;Serafino, Sara;Corano Scheri, Giuseppe;Pavone, Paolo;Alunni Fegatelli, Danilo;Mezzaroma, Ivano;Antonelli, Guido;Vullo, Vincenzo;Scagnolari, Carolina;D'ettorre, Gabriella
2017
Abstract
The gut microbiota is involved in the regulation of cognition, mood, anxiety, and pain, and can impact cognitive functions by producing neuroactive substances or releasing bacterial by-products and metabolites. No information is available on the effects of a probiotic supplementation on brain function of HIV+ subjects. In light of the above considerations, we performed a pilot study in cART-treated HIV-1-positive patients with long-term virologic suppression. The aims were to analyze the effect of high-concentration multistrain probiotic supplementation (Vivomixx®; Visbiome®) on several neurocognitive abilities and to evaluate the safety of this supplementation.| File | Dimensione | Formato | |
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