Gut microbiota has metabolic activity which influences mucosal homeostasis, local and systemic immune responses, and other anatomical systems (i.e., brain). The effects of dysbiosis are still poorly studied in Human Immunodeficiency Virus-1 (HIV-1) positive subjects and insufficient data are available on the impairment of the gut-brain axis, despite neurocognitive disorders being commonly diagnosed in these patients. This study evaluated the impact of a probiotic supplementation strategy on intrathecal immune activation and cognitive performance in combined antiretroviral therapy (cART) treated HIV-1 infected subjects.
Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals / Ceccarelli, Giancarlo; Brenchley, Jason M; Cavallari, Eugenio Nelson; Corano Scheri, Giuseppe; Fratino, Mariangela; Pinacchio, Claudia; Schietroma, Ivan; Najafi Fard, Saeid; Scagnolari, Carolina; Mezzaroma, Ivano; Vullo, Vincenzo; D'Ettorre, Gabriella. - In: NUTRIENTS. - ISSN 2072-6643. - 9:11(2016), p. 1269. [10.3390/nu9111269]
Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals
Ceccarelli, Giancarlo;Cavallari, Eugenio Nelson;Corano Scheri, Giuseppe;Fratino, Mariangela;Pinacchio, Claudia;Schietroma, Ivan;Najafi Fard, Saeid;Scagnolari, Carolina;Mezzaroma, Ivano;Vullo, Vincenzo;D'ettorre, Gabriella
2016
Abstract
Gut microbiota has metabolic activity which influences mucosal homeostasis, local and systemic immune responses, and other anatomical systems (i.e., brain). The effects of dysbiosis are still poorly studied in Human Immunodeficiency Virus-1 (HIV-1) positive subjects and insufficient data are available on the impairment of the gut-brain axis, despite neurocognitive disorders being commonly diagnosed in these patients. This study evaluated the impact of a probiotic supplementation strategy on intrathecal immune activation and cognitive performance in combined antiretroviral therapy (cART) treated HIV-1 infected subjects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
